The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

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dc.contributor.author Vannini, Nicola
dc.contributor.author Campos, Vasco
dc.contributor.author Girotra, Mukul
dc.contributor.author Trachsel, Vincent
dc.contributor.author Rojas-Sutterlin, Shanti
dc.contributor.author Tratwal, Josefine
dc.contributor.author Ragusa, Simone
dc.contributor.author Stefanidis, Evangelos
dc.contributor.author Ryu, Dongryeol
dc.contributor.author Rainer, Pernille Y.
dc.contributor.author Nikitin, Gena
dc.contributor.author Giger, Sonja
dc.contributor.author Li, Terytty Y.
dc.contributor.author Semilietof, Aikaterini
dc.contributor.author Oggier, Aurelien
dc.contributor.author Yersin, Yannick
dc.contributor.author Tauzin, Loic
dc.contributor.author Pirinen, Eija
dc.contributor.author Cheng, Wan-Chen
dc.contributor.author Ratajczak, Joanna
dc.contributor.author Canto, Carles
dc.contributor.author Ehrbar, Martin
dc.contributor.author Sizzano, Federico
dc.contributor.author Petrova, Tatiana V.
dc.contributor.author Vanhecke, Dominique
dc.contributor.author Zhang, Lianjun
dc.contributor.author Romero, Pedro
dc.contributor.author Nahimana, Aimable
dc.contributor.author Cherix, Stephane
dc.contributor.author Duchosal, Michel A.
dc.contributor.author Ho, Ping-Chih
dc.contributor.author Deplancke, Bart
dc.contributor.author Coukos, George
dc.contributor.author Auwerx, Johan
dc.contributor.author Lutolf, Matthias P.
dc.contributor.author Naveiras, Olaia
dc.date.accessioned 2021-02-03T07:59:01Z
dc.date.available 2021-02-03T07:59:01Z
dc.date.issued 2019-03-07
dc.identifier.citation Vannini , N , Campos , V , Girotra , M , Trachsel , V , Rojas-Sutterlin , S , Tratwal , J , Ragusa , S , Stefanidis , E , Ryu , D , Rainer , P Y , Nikitin , G , Giger , S , Li , T Y , Semilietof , A , Oggier , A , Yersin , Y , Tauzin , L , Pirinen , E , Cheng , W-C , Ratajczak , J , Canto , C , Ehrbar , M , Sizzano , F , Petrova , T V , Vanhecke , D , Zhang , L , Romero , P , Nahimana , A , Cherix , S , Duchosal , M A , Ho , P-C , Deplancke , B , Coukos , G , Auwerx , J , Lutolf , M P & Naveiras , O 2019 , ' The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance ' , Cell Stem Cell , vol. 24 , no. 3 , pp. 405-+ . https://doi.org/10.1016/j.stem.2019.02.012
dc.identifier.other PURE: 123523486
dc.identifier.other PURE UUID: 058848f9-c947-4235-9dfb-c08b64ea24a2
dc.identifier.other WOS: 000460672700013
dc.identifier.other Scopus: 85062074581
dc.identifier.uri http://hdl.handle.net/10138/325758
dc.description.abstract It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD(+)-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation. In immune-deficient mice, NR increased the production of human leucocytes from hCD34+ progenitors. Our work demonstrates for the first time a positive effect of NAD(+)-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision, and unveiling the potential of NR to improve recovery of patients suffering from hematological failure including post chemo- and radiotherapy. en
dc.format.extent 21
dc.language.iso eng
dc.relation.ispartof Cell Stem Cell
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject STEM-CELL TRANSPLANTATION
dc.subject GREEN FLUORESCENT PROTEIN
dc.subject SELF-RENEWAL
dc.subject LIFE-SPAN
dc.subject METABOLIC CHECKPOINT
dc.subject PROGENITOR CELLS
dc.subject MITOPHAGY
dc.subject AUTOPHAGY
dc.subject HOMEOSTASIS
dc.subject LONGEVITY
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance en
dc.type Article
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Department of Biochemistry and Developmental Biology
dc.contributor.organization Eija Pirinen / Principal Investigator
dc.contributor.organization Research Programs Unit
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.stem.2019.02.012
dc.relation.issn 1934-5909
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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