Dramatic increase in serum trypsinogens, SPINK1 and hCG beta in aortic surgery patients after hypothermic circulatory arrest

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Stewart , J A , Koistinen , R , Lempiäinen , A , Hotakainen , K , Salminen , U-S , Vakkuri , A , Wennervirta , J , Stenman , U-H & Koistinen , H 2020 , ' Dramatic increase in serum trypsinogens, SPINK1 and hCG beta in aortic surgery patients after hypothermic circulatory arrest ' , Scandinavian Journal of Clinical & Laboratory Investigation , vol. 80 , no. 8 , pp. 640-643 . https://doi.org/10.1080/00365513.2020.1824297

Title: Dramatic increase in serum trypsinogens, SPINK1 and hCG beta in aortic surgery patients after hypothermic circulatory arrest
Author: Stewart, Juhani A.; Koistinen, Riitta; Lempiäinen, Anna; Hotakainen, Kristina; Salminen, Ulla-Stina; Vakkuri, Anne; Wennervirta, Johanna; Stenman, Ulf-Hakan; Koistinen, Hannu
Contributor organization: Kardiologian yksikkö
Helsinki University Hospital Area
University of Helsinki
Medicum
HUSLAB
Department of Clinical Chemistry and Hematology
Päivi Hotakainen / Principal Investigator
HUS Heart and Lung Center
III kirurgian klinikka
Department of Surgery
HUS Perioperative, Intensive Care and Pain Medicine
Anestesiologian yksikkö
Clinicum
Department of Diagnostics and Therapeutics
HUS Abdominal Center
Date: 2020-12-01
Language: eng
Number of pages: 4
Belongs to series: Scandinavian Journal of Clinical & Laboratory Investigation
ISSN: 0036-5513
DOI: https://doi.org/10.1080/00365513.2020.1824297
URI: http://hdl.handle.net/10138/325867
Abstract: The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance of normal physiological homeostasis, without indication of the diseases they are normally associated with. To prevent false diagnoses and inappropriate treatments of critically ill patients, it is important that the markers aiding the selection of second-line treatments are evaluated in such patients and not only in the healthy population and patients with diseases the markers are associated with. The levels of trypsinogen isoenzymes, the trypsin inhibitor serine peptidase inhibitor Kazal type 1 (SPINK1), hCG and hCG beta, which are used as pancreatitis and cancer markers, were analyzed by immunoassays from serum samples of 17 adult patients who have undergone surgery of the ascending aorta during hypothermic circulatory arrest (HCA) with optional selective cerebral perfusion. Highly elevated levels of trypsinogen-1, -2 and -3, SPINK1 and hCG beta were observed in patients after HCA. This was accompanied by increased concentrations of S100 beta and NSE. In conclusion, this study highlights the importance of critically evaluating the markers used for aiding selection of second line of treatments in critically ill patients.
Subject: Hypothermic circulatory arrest
aortic surgery
biomarkers
critical illness
hCG beta
SPINK1
trypsin
trypsinogen
VALIDATION
DIAGNOSIS
AMYLASE
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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