Extended family history of type 1 diabetes inHLA-predisposed children with and without islet autoantibodies

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dc.contributor.author Kuusela, Salla
dc.contributor.author Keskinen, Päivi
dc.contributor.author Pokka, Tytti
dc.contributor.author Knip, Mikael
dc.contributor.author Ilonen, Jorma
dc.contributor.author Vähäsalo, Paula
dc.contributor.author Veijola, Riitta
dc.date.accessioned 2021-02-04T09:40:01Z
dc.date.available 2021-02-04T09:40:01Z
dc.date.issued 2020-12
dc.identifier.citation Kuusela , S , Keskinen , P , Pokka , T , Knip , M , Ilonen , J , Vähäsalo , P & Veijola , R 2020 , ' Extended family history of type 1 diabetes inHLA-predisposed children with and without islet autoantibodies ' , Pediatric Diabetes , vol. 21 , no. 8 , pp. 1447-1456 . https://doi.org/10.1111/pedi.13122
dc.identifier.other PURE: 149532401
dc.identifier.other PURE UUID: 187a8077-79db-4bcc-8752-44a751bef8e4
dc.identifier.other WOS: 000574050400001
dc.identifier.uri http://hdl.handle.net/10138/325878
dc.description.abstract Objective The aim of this study was to explore the extended family history of type 1 diabetes in children at genetic risk and define the impact of a positive family history on the development of islet autoimmunity and type 1 diabetes. Methods The subjects were participants in The Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study and carried increased HLA-conferred risk for type 1 diabetes. The case children (N = 343) were positive for at least one islet autoantibody, and the control children (N = 343) matched by age, gender and class II HLA genotype were negative for islet autoantibodies at the time of data collection. Extended family history of type 1 diabetes was obtained by using a structured questionnaire. Results Among children who were autoantibody positive and progressed to type 1 diabetes 62.2% (28/45) had at least one relative with type 1 diabetes. Interestingly, 57.8% of these children (26/45) had such a relative outside the nuclear family compared to 30.7% of children with no autoantibodies (P= .001), 35.2% of those with only classical islet cell antibodies (P= .006), and 35.2% of non-progressors with biochemical autoantibodies (P= 0.011). A positive history of type 1 diabetes in the paternal extended family was more common in children with multiple biochemical autoantibodies compared to those with only one biochemical autoantibody (P= .010). No association between the specificity of the first appearing autoantibody and family history of the disease was found. Conclusions Type 1 diabetes in relatives outside the nuclear family is a significant risk factor for islet autoimmunity and progression to clinical disease in HLA susceptible children. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Pediatric Diabetes
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject children
dc.subject family history
dc.subject genetic risk
dc.subject HLA
dc.subject islet autoimmunity
dc.subject type 1 diabetes
dc.subject BETA-CELL AUTOIMMUNITY
dc.subject GENETIC SUSCEPTIBILITY
dc.subject RISK
dc.subject POPULATION
dc.subject MELLITUS
dc.subject MOTHERS
dc.subject 3123 Gynaecology and paediatrics
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Extended family history of type 1 diabetes inHLA-predisposed children with and without islet autoantibodies en
dc.type Article
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Children's Hospital
dc.contributor.organization Research Programs Unit
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Faculty of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/pedi.13122
dc.relation.issn 1399-543X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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