Diffusion tensor imaging in frontostriatal tracts is associated with executive functioning in very preterm children at 9 years of age

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http://hdl.handle.net/10138/325885

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Kallankari , H , Saunavaara , V , Parkkola , R , Haataja , L , Hallman , M & Kaukola , T 2021 , ' Diffusion tensor imaging in frontostriatal tracts is associated with executive functioning in very preterm children at 9 years of age ' , Pediatric Radiology , vol. 51 , no. 1 , pp. 112–118 . https://doi.org/10.1007/s00247-020-04802-1

Title: Diffusion tensor imaging in frontostriatal tracts is associated with executive functioning in very preterm children at 9 years of age
Author: Kallankari, Hanna; Saunavaara, Virva; Parkkola, Riitta; Haataja, Leena; Hallman, Mikko; Kaukola, Tuula
Contributor: University of Helsinki, HUS Children and Adolescents
Date: 2021-01
Language: eng
Number of pages: 7
Belongs to series: Pediatric Radiology
ISSN: 0301-0449
URI: http://hdl.handle.net/10138/325885
Abstract: Background Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later. Objective The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor imaging metrics of frontostriatal tracts correlate to executive functioning. Materials and methods The prospective cohort study comprised 54 very preterm children (mean gestational age 28.8 weeks) and 20 age- and gender-matched term children. None of the children had severe neurologic impairment. The children underwent diffusion tensor imaging and neuropsychological assessments at a mean age of 9 years. We measured quantitative diffusion tensor imaging metrics of frontostriatal tracts using probabilistic tractography. We also administered five subtests from the Developmental Neuropsychological Assessment, Second Edition, to evaluate executive functioning. Results Very preterm children had significantly higher fractional anisotropy and axial diffusivity values (P
Subject: Children
Diffusion tensor imaging
Frontostriatal tracts
Magnetic resonance imaging
Premature birth
Tractography
White matter
WHITE-MATTER ALTERATIONS
FETAL-GROWTH RESTRICTION
BORN PRETERM
ADULTS BORN
BIRTH
INFANTS
MICROSTRUCTURE
ABNORMALITIES
CONNECTIVITY
PATHWAYS
3123 Gynaecology and paediatrics
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