Impact of smoking on gestational diabetes mellitus and offspring birthweight in primiparous women

Show full item record



Masalin , S , Kautiainen , H , Gissler , M , Pennanen , P , Eriksson , J G & Laine , M K 2020 , ' Impact of smoking on gestational diabetes mellitus and offspring birthweight in primiparous women ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 99 , no. 12 , pp. 1632-1639 .

Title: Impact of smoking on gestational diabetes mellitus and offspring birthweight in primiparous women
Author: Masalin, Senja; Kautiainen, Hannu; Gissler, Mika; Pennanen, Pirjo; Eriksson, Johan G.; Laine, Merja K.
Contributor organization: HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
University of Helsinki
Helsinki University Hospital Area
Department of General Practice and Primary Health Care
Research Programs Unit
Johan Eriksson / Principal Investigator
Date: 2020-12
Language: eng
Number of pages: 8
Belongs to series: Acta Obstetricia et Gynecologica Scandinavica
ISSN: 0001-6349
Abstract: Introduction Smoking has been shown to affect glucose homeostasis and increase the risk for type 2 diabetes mellitus. Further, gestational diabetes mellitus (GDM) and smoking are known to influence offspring birthweight. The effect of smoking on glucose homeostasis in pregnancy is less studied and the findings are inconsistent. The aim of this study was to evaluate the effect of smoking on risk for GDM and to evaluate the impact of smoking and GDM on offspring birthweight. Material and methods This is an observational cohort study encompassing 4111 Finnish primiparous women from the city of Vantaa, Finland, who delivered a singleton child between 2009 and 2015. Data were obtained from Finnish national registers. Study participants had complete oral glucose tolerance test results and were divided into three groups according to smoking status: non-smokers (I), smokers who quit during first trimester (II), and smokers who continued after first trimester (III). Results Prevalence of GDM was 19.8%, 24.3%, and 26.6% in non-smokers, those who quit, and those who continued after the first trimester, respectively (P = .004 for differences between groups). The odds ratio for GDM in smokers who continued after the first trimester compared with non-smokers was 1.65 (95% CI 1.09-2.57) after adjustments for age, prepregnancy body mass index, education, and cohabitation. In women without GDM, offspring birthweight was lowest in those who continued smoking after the first trimester (P = .010 for differences between groups). In women with GDM, smoking status did not influence offspring birthweight. Conclusions Smoking during pregnancy is associated with an increased risk for GDM. Offspring birthweight is lowest in women who continue smoking after the first trimester. If pregnancy is complicated by GDM, offspring birthweight is not influenced by smoking.
Subject: birthweight
gestational diabetes mellitus
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
aogs.13924.pdf 661.4Kb PDF View/Open
Impact_of_smoki ... t_in_primiparous_women.pdf 11.72Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record