Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study

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http://hdl.handle.net/10138/325912

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Benoni , H , Eloranta , S , Dahle , D O , Svensson , M H S , Nordin , A , Carstens , J , Mjoen , G , Helanterä , I , Hellstrom , V , Enblad , G , Pukkala , E , Sorensen , S S , Lempinen , M & Smedby , K E 2020 , ' Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study ' , Transplant International , vol. 33 , no. 12 , pp. 1700-1710 . https://doi.org/10.1111/tri.13734

Title: Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study
Author: Benoni, Henrik; Eloranta, Sandra; Dahle, Dag O.; Svensson, My H. S.; Nordin, Arno; Carstens, Jan; Mjoen, Geir; Helanterä, Ilkka; Hellstrom, Vivan; Enblad, Gunilla; Pukkala, Eero; Sorensen, Soren S.; Lempinen, Marko; Smedby, Karin E.
Contributor organization: HUS Abdominal Center
IV kirurgian klinikka
Helsinki University Hospital Area
Nefrologian yksikkö
Date: 2020-12
Language: eng
Number of pages: 11
Belongs to series: Transplant International
ISSN: 0934-0874
DOI: https://doi.org/10.1111/tri.13734
URI: http://hdl.handle.net/10138/325912
Abstract: Kidney transplant recipients (KTRs) have an increased cancer risk compared to the general population, but absolute risks that better reflect the clinical impact of cancer are seldom estimated. All KTRs in Sweden, Norway, Denmark, and Finland, with a first transplantation between 1995 and 2011, were identified through national registries. Post-transplantation cancer occurrence was assessed through linkage with cancer registries. We estimated standardized incidence ratios (SIR), absolute excess risks (AER), and cumulative incidence of cancer in the presence of competing risks. Overall, 12 984 KTRs developed 2215 cancers. The incidence rate of cancer overall was threefold increased (SIR 3.3, 95% confidence interval [CI]: 3.2-3.4). The AER of any cancer was 1560 cases (95% CI: 1468-1656) per 100 000 person-years. The highest AERs were observed for nonmelanoma skin cancer (838, 95% CI: 778-901), non-Hodgkin lymphoma (145, 95% CI: 119-174), lung cancer (126, 95% CI: 98.2-149), and kidney cancer (122, 95% CI: 98.0-149). The five- and ten-year cumulative incidence of any cancer was 8.1% (95% CI: 7.6-8.6%) and 16.8% (95% CI: 16.0-17.6%), respectively. Excess cancer risks were observed among Nordic KTRs for a wide range of cancers. Overall, 1 in 6 patients developed cancer within ten years, supporting extensive post-transplantation cancer vigilance.
Subject: cancer
incidence
malignancy
risk
transplantation
RENAL-TRANSPLANTATION
ORGAN-TRANSPLANTATION
NATIONWIDE COHORT
MALIGNANCIES
TAIWAN
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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