Frequency of fatigue and its changes in the first 6 months after traumatic brain injury : results from the CENTER-TBI study

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dc.contributor.author CTR-TBI Participants Investigators
dc.contributor.author Andelic, Nada
dc.contributor.author Roe, Cecilie
dc.contributor.author Brunborg, Cathrine
dc.contributor.author von Steinbuechel, Nicole
dc.contributor.author Palotie, Aarno
dc.contributor.author Piippo-Karjalainen, Anna
dc.contributor.author Pirinen, Matti
dc.contributor.author Raj, Rahul
dc.contributor.author Ripatti, Samuli
dc.date.accessioned 2021-02-05T08:07:01Z
dc.date.available 2021-02-05T08:07:01Z
dc.date.issued 2021-01
dc.identifier.citation CTR-TBI Participants Investigators , Andelic , N , Roe , C , Brunborg , C , von Steinbuechel , N , Palotie , A , Piippo-Karjalainen , A , Pirinen , M , Raj , R & Ripatti , S 2021 , ' Frequency of fatigue and its changes in the first 6 months after traumatic brain injury : results from the CENTER-TBI study ' , Journal of Neurology , vol. 268 , no. 1 , pp. 61–73 . https://doi.org/10.1007/s00415-020-10022-2
dc.identifier.other PURE: 159516199
dc.identifier.other PURE UUID: b9748c93-77ac-41a8-9d83-2845eddea740
dc.identifier.other WOS: 000549344200002
dc.identifier.other ORCID: /0000-0002-1664-1350/work/88205784
dc.identifier.other ORCID: /0000-0002-2527-5874/work/97266244
dc.identifier.uri http://hdl.handle.net/10138/325959
dc.description.abstract Background Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. Results Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. Conclusion A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Journal of Neurology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Head injury
dc.subject Post-traumatic fatigue
dc.subject Longitudinal studies
dc.subject Neurological disorders
dc.subject CONCUSSION SYMPTOMS QUESTIONNAIRE
dc.subject GENERAL-POPULATION
dc.subject GENDER-DIFFERENCES
dc.subject SEVERITY
dc.subject PREVALENCE
dc.subject PREDICTORS
dc.subject RECOVERY
dc.subject OUTCOMES
dc.subject SLEEP
dc.subject MODEL
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Frequency of fatigue and its changes in the first 6 months after traumatic brain injury : results from the CENTER-TBI study en
dc.type Article
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Research Programs Unit
dc.contributor.organization Aarno Palotie / Principal Investigator
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurokirurgian yksikkö
dc.contributor.organization Helsinki Institute for Information Technology
dc.contributor.organization Statistical and population genetics
dc.contributor.organization Department of Mathematics and Statistics
dc.contributor.organization Biostatistics Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Samuli Olli Ripatti / Principal Investigator
dc.contributor.organization Complex Disease Genetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00415-020-10022-2
dc.relation.issn 0340-5354
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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