Considerations for the design and conduct of human gut microbiota intervention studies relating to foods

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Swann , J R , Rajilic-Stojanovic , M , Salonen , A , Sakwinska , O , Gill , C , Meynier , A , Fanca-Berthon , P , Schelkle , B , Segata , N , Shortt , C , Tuohy , K & Hasselwander , O 2020 , ' Considerations for the design and conduct of human gut microbiota intervention studies relating to foods ' , European Journal of Nutrition , vol. 59 , no. 8 , pp. 3347-3368 . https://doi.org/10.1007/s00394-020-02232-1

Title: Considerations for the design and conduct of human gut microbiota intervention studies relating to foods
Author: Swann, J. R.; Rajilic-Stojanovic, M.; Salonen, A.; Sakwinska, O.; Gill, C.; Meynier, A.; Fanca-Berthon, P.; Schelkle, B.; Segata, N.; Shortt, C.; Tuohy, K.; Hasselwander, O.
Contributor: University of Helsinki, HUMI - Human Microbiome Research
Date: 2020-12
Language: eng
Number of pages: 22
Belongs to series: European Journal of Nutrition
ISSN: 1436-6207
URI: http://hdl.handle.net/10138/325993
Abstract: With the growing appreciation for the influence of the intestinal microbiota on human health, there is increasing motivation to design and refine interventions to promote favorable shifts in the microbiota and their interactions with the host. Technological advances have improved our understanding and ability to measure this indigenous population and the impact of such interventions. However, the rapid growth and evolution of the field, as well as the diversity of methods used, parameters measured and populations studied, make it difficult to interpret the significance of the findings and translate their outcomes to the wider population. This can prevent comparisons across studies and hinder the drawing of appropriate conclusions. This review outlines considerations to facilitate the design, implementation and interpretation of human gut microbiota intervention studies relating to foods based upon our current understanding of the intestinal microbiota, its functionality and interactions with the human host. This includes parameters associated with study design, eligibility criteria, statistical considerations, characterization of products and the measurement of compliance. Methodologies and markers to assess compositional and functional changes in the microbiota, following interventions are discussed in addition to approaches to assess changes in microbiota-host interactions and host responses. Last, EU legislative aspects in relation to foods and health claims are presented. While it is appreciated that the field of gastrointestinal microbiology is rapidly evolving, such guidance will assist in the design and interpretation of human gut microbiota interventional studies relating to foods.
Subject: Microbiota
Microbiome
Gut bacteria
Intestinal microbes
Human studies
Foods
Prebiotics
Probiotics
INTERNATIONAL SCIENTIFIC ASSOCIATION
RANDOMIZED CONTROLLED-TRIAL
DIETARY FIBER INTAKE
AKKERMANSIA-MUCINIPHILA
CONSENSUS STATEMENT
CLINICAL-RESPONSE
ACID COMPOSITION
HEALTH-BENEFITS
DOUBLE-BLIND
WHOLE-GRAIN
3143 Nutrition
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