Considerations for the design and conduct of human gut microbiota intervention studies relating to foods

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dc.contributor.author Swann, J. R.
dc.contributor.author Rajilic-Stojanovic, M.
dc.contributor.author Salonen, A.
dc.contributor.author Sakwinska, O.
dc.contributor.author Gill, C.
dc.contributor.author Meynier, A.
dc.contributor.author Fanca-Berthon, P.
dc.contributor.author Schelkle, B.
dc.contributor.author Segata, N.
dc.contributor.author Shortt, C.
dc.contributor.author Tuohy, K.
dc.contributor.author Hasselwander, O.
dc.date.accessioned 2021-02-05T10:32:00Z
dc.date.available 2021-02-05T10:32:00Z
dc.date.issued 2020-12
dc.identifier.citation Swann , J R , Rajilic-Stojanovic , M , Salonen , A , Sakwinska , O , Gill , C , Meynier , A , Fanca-Berthon , P , Schelkle , B , Segata , N , Shortt , C , Tuohy , K & Hasselwander , O 2020 , ' Considerations for the design and conduct of human gut microbiota intervention studies relating to foods ' , European Journal of Nutrition , vol. 59 , no. 8 , pp. 3347-3368 . https://doi.org/10.1007/s00394-020-02232-1
dc.identifier.other PURE: 136253615
dc.identifier.other PURE UUID: 89ae2537-483d-4af1-9fb4-8c3dcc123265
dc.identifier.other WOS: 000523112300003
dc.identifier.other ORCID: /0000-0002-6960-7447/work/88203182
dc.identifier.uri http://hdl.handle.net/10138/325993
dc.description.abstract With the growing appreciation for the influence of the intestinal microbiota on human health, there is increasing motivation to design and refine interventions to promote favorable shifts in the microbiota and their interactions with the host. Technological advances have improved our understanding and ability to measure this indigenous population and the impact of such interventions. However, the rapid growth and evolution of the field, as well as the diversity of methods used, parameters measured and populations studied, make it difficult to interpret the significance of the findings and translate their outcomes to the wider population. This can prevent comparisons across studies and hinder the drawing of appropriate conclusions. This review outlines considerations to facilitate the design, implementation and interpretation of human gut microbiota intervention studies relating to foods based upon our current understanding of the intestinal microbiota, its functionality and interactions with the human host. This includes parameters associated with study design, eligibility criteria, statistical considerations, characterization of products and the measurement of compliance. Methodologies and markers to assess compositional and functional changes in the microbiota, following interventions are discussed in addition to approaches to assess changes in microbiota-host interactions and host responses. Last, EU legislative aspects in relation to foods and health claims are presented. While it is appreciated that the field of gastrointestinal microbiology is rapidly evolving, such guidance will assist in the design and interpretation of human gut microbiota interventional studies relating to foods. en
dc.format.extent 22
dc.language.iso eng
dc.relation.ispartof European Journal of Nutrition
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Microbiota
dc.subject Microbiome
dc.subject Gut bacteria
dc.subject Intestinal microbes
dc.subject Human studies
dc.subject Foods
dc.subject Prebiotics
dc.subject Probiotics
dc.subject INTERNATIONAL SCIENTIFIC ASSOCIATION
dc.subject RANDOMIZED CONTROLLED-TRIAL
dc.subject DIETARY FIBER INTAKE
dc.subject AKKERMANSIA-MUCINIPHILA
dc.subject CONSENSUS STATEMENT
dc.subject CLINICAL-RESPONSE
dc.subject ACID COMPOSITION
dc.subject HEALTH-BENEFITS
dc.subject DOUBLE-BLIND
dc.subject WHOLE-GRAIN
dc.subject 3143 Nutrition
dc.title Considerations for the design and conduct of human gut microbiota intervention studies relating to foods en
dc.type Review Article
dc.contributor.organization HUMI - Human Microbiome Research
dc.contributor.organization Clinicum
dc.contributor.organization de Vos & Salonen group
dc.contributor.organization Research Programs Unit
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00394-020-02232-1
dc.relation.issn 1436-6207
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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