The prognostic role of tissue TLR2 and TLR4 in colorectal cancer

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Beilmann-Lehtonen , I , Böckelman , C , Mustonen , H , Koskensalo , S , Hagström , J & Haglund , C 2020 , ' The prognostic role of tissue TLR2 and TLR4 in colorectal cancer ' , Virchows Archiv , vol. 477 , no. 5 , pp. 705–715 . https://doi.org/10.1007/s00428-020-02833-5

Title: The prognostic role of tissue TLR2 and TLR4 in colorectal cancer
Author: Beilmann-Lehtonen, Ines; Böckelman, Camilla; Mustonen, Harri; Koskensalo, Selja; Hagström, Jaana; Haglund, Caj
Other contributor: University of Helsinki, Department of Surgery
University of Helsinki, Clinicum
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Abdominal Center












Date: 2020
Language: eng
Number of pages: 11
Belongs to series: Virchows Archiv
ISSN: 0945-6317
DOI: https://doi.org/10.1007/s00428-020-02833-5
URI: http://hdl.handle.net/10138/325994
Abstract: Colorectal cancer (CRC), the second most common cancer globally, resulted in 881,000 deaths in 2018. Toll-like receptors (TLRs) are crucial to detecting pathogen invasion and inducing the host's immune response. This study aimed to explore the prognostic value of TLR2 and TLR4 tumor expressions in colorectal cancer patients. We studied the immunohistochemical expressions of TLR2 and TLR4 using tissue microarray specimens from 825 patients undergoing surgery in the Department of Surgery, Helsinki University Hospital, between 1982 and 2002. We assessed the relationships between TLR2 and TLR4 expressions and clinicopathological variables and patient survival. We generated survival curves using the Kaplan-Meier method, determining significance with the log-rank test. Among patients with lymph node-positive disease and no distant metastases (Dukes C), a strong TLR2 immunoactivity associated with a better prognosis (p <0.001). Among patients with local Dukes B disease, a strong TLR4 immunoactivity associated with a worse disease-specific survival (DSS; p = 0.017). In the multivariate survival analysis, moderate TLR4 immunoactivity compared with strong TLR4 immunoactivity (hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.49-0.89, p = 0.007) served as an independent prognostic factor. In the multivariate analysis for the Dukes subgroups, moderate TLR2 immunoactivity (HR 2.63, 95% CI 1.56-4.44, p <0.001) compared with strong TLR2 immunoactivity served as an independent negative prognostic factor in the Dukes C subgroup. TLR2 and TLR4 might be new prognostic factors to indicate which CRC patients require adjuvant therapy and which could spare from an unnecessary follow-up, but further investigations are needed.
Subject: Toll-like receptor 2
Toll-like receptor 4
Colorectal cancer
Colon cancer
Immunohistochemistry
TOLL-LIKE RECEPTORS
COLON-CANCER
EXPRESSION
INFLAMMATION
PROMOTES
TUMOR
LIGANDS
3111 Biomedicine
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
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