The prognostic role of tissue TLR2 and TLR4 in colorectal cancer

Show full item record



Beilmann-Lehtonen , I , Böckelman , C , Mustonen , H K , Hagström , J , Koskensalo , S & Haglund , C 2020 , ' The prognostic role of tissue TLR2 and TLR4 in colorectal cancer ' , Virchows Archiv , vol. 477 , no. 5 , pp. 705–715 .

Title: The prognostic role of tissue TLR2 and TLR4 in colorectal cancer
Author: Beilmann-Lehtonen, Ines; Böckelman, Camilla; Mustonen, Harri K; Hagström, Jaana; Koskensalo, Selja; Haglund, Caj
Contributor organization: Faculty of Medicine
HUS Abdominal Center
HUS Head and Neck Center
II kirurgian klinikka
Department of Surgery
Date: 2020-05-19
Language: eng
Number of pages: 11
Belongs to series: Virchows Archiv
ISSN: 0945-6317
Abstract: Colorectal cancer (CRC), the second most common cancer globally, resulted in 881,000 deaths in 2018. Toll-like receptors (TLRs) are crucial to detecting pathogen invasion and inducing the host's immune response. This study aimed to explore the prognostic value of TLR2 and TLR4 tumor expressions in colorectal cancer patients. We studied the immunohistochemical expressions of TLR2 and TLR4 using tissue microarray specimens from 825 patients undergoing surgery in the Department of Surgery, Helsinki University Hospital, between 1982 and 2002. We assessed the relationships between TLR2 and TLR4 expressions and clinicopathological variables and patient survival. We generated survival curves using the Kaplan-Meier method, determining significance with the log-rank test. Among patients with lymph node-positive disease and no distant metastases (Dukes C), a strong TLR2 immunoactivity associated with a better prognosis (p <0.001). Among patients with local Dukes B disease, a strong TLR4 immunoactivity associated with a worse disease-specific survival (DSS; p = 0.017). In the multivariate survival analysis, moderate TLR4 immunoactivity compared with strong TLR4 immunoactivity (hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.49-0.89, p = 0.007) served as an independent prognostic factor. In the multivariate analysis for the Dukes subgroups, moderate TLR2 immunoactivity (HR 2.63, 95% CI 1.56-4.44, p <0.001) compared with strong TLR2 immunoactivity served as an independent negative prognostic factor in the Dukes C subgroup. TLR2 and TLR4 might be new prognostic factors to indicate which CRC patients require adjuvant therapy and which could spare from an unnecessary follow-up, but further investigations are needed.
Subject: Toll-like receptor 2
Toll-like receptor 4
Colorectal cancer
Colon cancer
3111 Biomedicine
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Beilmann_Lehton ... osticRoleOfTissueTLR2A.pdf 1.540Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record