Endotoxemia is associated with an adverse metabolic profile

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Määttä , A , Salminen , A , Pietiäinen , M , Leskelä , J , Palviainen , T , Sattler , W , Sinisalo , J , Salomaa , V , Kaprio , J & Pussinen , P 2021 , ' Endotoxemia is associated with an adverse metabolic profile ' , Innate Immunity , vol. 27 , no. 1 , pp. 3-14 . https://doi.org/10.1177/1753425920971702

Title: Endotoxemia is associated with an adverse metabolic profile
Author: Määttä, Anne; Salminen, Aino; Pietiäinen, Milla; Leskelä, Jaakko; Palviainen, Teemu; Sattler, Wolfgang; Sinisalo, Juha; Salomaa, Veikko; Kaprio, Jaakko; Pussinen, Pirkko
Contributor organization: Department of Oral and Maxillofacial Diseases
University of Helsinki
Helsinki University Hospital Area
HUS Head and Neck Center
Institute for Molecular Medicine Finland
Genetic Epidemiology
HUS Heart and Lung Center
Department of Medicine
Clinicum
Department of Public Health
Date: 2021-01
Language: eng
Number of pages: 12
Belongs to series: Innate Immunity
ISSN: 1753-4259
DOI: https://doi.org/10.1177/1753425920971702
URI: http://hdl.handle.net/10138/326078
Abstract: Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separately and in a meta-analysis (n = 7178), namely population-based FINRISK97, FinnTwin16 consisting of young adult twins, and Parogene, a random cohort of cardiac patients. Endotoxemia was determined as serum LPS activity and metabolome by an NMR platform. Potential effects of body mass index (BMI), smoking, metabolic syndrome (MetS), and coronary heart disease (CHD) status were considered. Endotoxemia was directly associated with concentrations of VLDL, IDL, LDL, and small HDL lipoproteins, VLDL particle diameter, total fatty acids (FA), glycoprotein acetyls (GlycA), aromatic and branched-chain amino acids, and Glc, and inversely associated with concentration of large HDL, diameters of LDL and HDL, as well as unsaturation degree of FAs. Some of these disadvantageous associations were significantly stronger in smokers and subjects with high BMI, but did not differ between participants with different CHD status. In participants with MetS, however, the associations of endotoxemia with FA parameters and GlycA were particularly strong. The metabolic profile in endotoxemia appears highly adverse, involving several inflammatory characters and risk factors for cardiometabolic disorders.
Subject: Endotoxemia
infection
inflammation
lipoproteins
metabolic syndrome
metabolomics
1182 Biochemistry, cell and molecular biology
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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