Streptococci and the complement system : interplay during infection, inflammation and autoimmunity

Show full item record



Permalink

http://hdl.handle.net/10138/326342

Citation

Syed , S , Viazmina , L , Mager , R , Meri , S & Haapasalo , K 2020 , ' Streptococci and the complement system : interplay during infection, inflammation and autoimmunity ' , FEBS Letters , vol. 594 , no. 16 , pp. 2570-2585 . https://doi.org/10.1002/1873-3468.13872

Title: Streptococci and the complement system : interplay during infection, inflammation and autoimmunity
Author: Syed, Shahan; Viazmina, Larisa; Mager, Riccardo; Meri, Seppo; Haapasalo, Karita
Contributor: University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, HUSLAB
University of Helsinki, Department of Bacteriology and Immunology
Date: 2020-08
Language: eng
Number of pages: 16
Belongs to series: FEBS Letters
ISSN: 0014-5793
URI: http://hdl.handle.net/10138/326342
Abstract: Streptococci are a broad group of Gram-positive bacteria. This genus includes various human pathogens causing significant morbidity and mortality. Two of the most important human pathogens areStreptococcus pneumoniae(pneumococcus) andStreptococcus pyogenes(group A streptococcus or GAS). Streptococcal pathogens have evolved to express virulence factors that enable them to evade complement-mediated attack. These include factor H-binding M (S. pyogenes) and pneumococcal surface protein C (PspC) (S. pneumoniae) proteins. In addition,S. pyogenesandS. pneumoniaeexpress cytolysins (streptolysin and pneumolysin), which are able to destroy host cells. Sometimes, the interplay between streptococci, the complement, and antistreptococcal immunity may lead to an excessive inflammatory response or autoimmune disease. Understanding the fundamental role of the complement system in microbial clearance and the bacterial escape mechanisms is of paramount importance for understanding microbial virulence, in general, and, the conversion of commensals to pathogens, more specifically. Such insights may help to identify novel antibiotic and vaccine targets in bacterial pathogens to counter their growing resistance to commonly used antibiotics.
Subject: autoreactivity
immune evasion
innate immunity
C-REACTIVE PROTEIN
INHIBITOR C4B-BINDING PROTEIN
INVASIVE PNEUMOCOCCAL DISEASE
GRAM-POSITIVE BACTERIA
GROUP-A STREPTOCOCCUS
REGULATOR FACTOR-H
SURFACE-PROTEINS
IN-VIVO
BINDING-PROTEIN
PNEUMONIAE
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1873_3468.13872.pdf 1.049Mb PDF View/Open
Streptococci_an ... ation_and_autoimmunity.pdf 16.65Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record