Syed , S , Viazmina , L , Mager , R , Meri , S & Haapasalo , K 2020 , ' Streptococci and the complement system : interplay during infection, inflammation and autoimmunity ' , FEBS Letters , vol. 594 , no. 16 , pp. 2570-2585 . https://doi.org/10.1002/1873-3468.13872
Title: | Streptococci and the complement system : interplay during infection, inflammation and autoimmunity |
Author: | Syed, Shahan; Viazmina, Larisa; Mager, Riccardo; Meri, Seppo; Haapasalo, Karita |
Contributor organization: | Department of Bacteriology and Immunology University of Helsinki HUSLAB Seppo Meri / Principal Investigator |
Date: | 2020-08 |
Language: | eng |
Number of pages: | 16 |
Belongs to series: | FEBS Letters |
ISSN: | 0014-5793 |
DOI: | https://doi.org/10.1002/1873-3468.13872 |
URI: | http://hdl.handle.net/10138/326342 |
Abstract: | Streptococci are a broad group of Gram-positive bacteria. This genus includes various human pathogens causing significant morbidity and mortality. Two of the most important human pathogens areStreptococcus pneumoniae(pneumococcus) andStreptococcus pyogenes(group A streptococcus or GAS). Streptococcal pathogens have evolved to express virulence factors that enable them to evade complement-mediated attack. These include factor H-binding M (S. pyogenes) and pneumococcal surface protein C (PspC) (S. pneumoniae) proteins. In addition,S. pyogenesandS. pneumoniaeexpress cytolysins (streptolysin and pneumolysin), which are able to destroy host cells. Sometimes, the interplay between streptococci, the complement, and antistreptococcal immunity may lead to an excessive inflammatory response or autoimmune disease. Understanding the fundamental role of the complement system in microbial clearance and the bacterial escape mechanisms is of paramount importance for understanding microbial virulence, in general, and, the conversion of commensals to pathogens, more specifically. Such insights may help to identify novel antibiotic and vaccine targets in bacterial pathogens to counter their growing resistance to commonly used antibiotics. |
Subject: |
autoreactivity
immune evasion innate immunity C-REACTIVE PROTEIN INHIBITOR C4B-BINDING PROTEIN INVASIVE PNEUMOCOCCAL DISEASE GRAM-POSITIVE BACTERIA GROUP-A STREPTOCOCCUS REGULATOR FACTOR-H SURFACE-PROTEINS IN-VIVO BINDING-PROTEIN PNEUMONIAE 3111 Biomedicine 1182 Biochemistry, cell and molecular biology |
Peer reviewed: | Yes |
Rights: | unspecified |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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