Adipokine Leptin Co-operates With Mechanosensitive Ca2+-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

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dc.contributor.author Acheva, Anna
dc.contributor.author Kärki, Tytti
dc.contributor.author Schaible, Niccole
dc.contributor.author Krishnan, Ramaswamy
dc.contributor.author Tojkander, Sari
dc.date.accessioned 2021-02-11T13:57:01Z
dc.date.available 2021-02-11T13:57:01Z
dc.date.issued 2021-01-06
dc.identifier.citation Acheva , A , Kärki , T , Schaible , N , Krishnan , R & Tojkander , S 2021 , ' Adipokine Leptin Co-operates With Mechanosensitive Ca 2+ -Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells ' , Frontiers in Cell and Developmental Biology , vol. 8 , 607038 . https://doi.org/10.3389/fcell.2020.607038
dc.identifier.other PURE: 160280784
dc.identifier.other PURE UUID: 20b2d4f8-9255-4c58-b1f6-29626ad914c6
dc.identifier.other WOS: 000608808400001
dc.identifier.other ORCID: /0000-0001-9447-8977/work/88677698
dc.identifier.uri http://hdl.handle.net/10138/326360
dc.description.abstract In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying mechanisms remain unclear. Here we show that treatment of normal mammary epithelial cells with leptin induces EMT-like features characterized by higher cellular migration speeds, loss of structural ordering of 3D-mammo spheres, and enhancement of epithelial traction forces. Mechanistically, leptin triggers the phosphorylation of myosin light chain kinase-2 (MLC-2) through the interdependent activity of leptin receptor and Ca2+ channels. These data provide evidence that leptin-activated leptin receptors, in co-operation with mechanosensitive Ca2+ channels, play a role in the development of breast carcinomas through the regulation of actomyosin dynamics. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Frontiers in Cell and Developmental Biology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject adipokines
dc.subject actomyosin
dc.subject calcium
dc.subject actin
dc.subject epithelium
dc.subject MESENCHYMAL TRANSITION
dc.subject CANCER CELLS
dc.subject MYOSIN-II
dc.subject MOLECULAR-MECHANISMS
dc.subject CONTRACTILE FORCES
dc.subject ADIPONECTIN
dc.subject ADIPOCYTES
dc.subject EXPRESSION
dc.subject INVASION
dc.subject RECEPTOR
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 3122 Cancers
dc.title Adipokine Leptin Co-operates With Mechanosensitive Ca2+-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells en
dc.type Article
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Soluvälitteiset voimat syöpäsolujen invaasiossa
dc.contributor.organization Veterinary Pathology and Parasitology
dc.contributor.organization Biosciences
dc.contributor.organization Helsinki One Health (HOH)
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fcell.2020.607038
dc.relation.issn 2296-634X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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