The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study

Visa fullständig post



Permalänk

http://hdl.handle.net/10138/326373

Citation

Haljas , K , Hakaste , L , Lahti , J , Isomaa , B , Groop , L , Tuomi , T & Räikkönen , K 2019 , ' The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study ' , Annals of Medicine , vol. 51 , no. 1 , pp. 58-67 . https://doi.org/10.1080/07853890.2018.1564357

Titel: The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study
Författare: Haljas, Kadri; Hakaste, Liisa; Lahti, Jari; Isomaa, Bo; Groop, Leif; Tuomi, Tiinamaija; Räikkönen, Katri
Upphovmannens organisation: Department of Psychology and Logopedics
Doctoral Programme in Cognition, Learning, Instruction and Communication
Medicum
Endokrinologian yksikkö
Clinicum
Helsinki Collegium for Advanced Studies
University of Helsinki
Centre of Excellence in Complex Disease Genetics
Institute for Molecular Medicine Finland
HUS Abdominal Center
Developmental Psychology Research Group
Datum: 2019-01-02
Språk: eng
Sidantal: 10
Tillhör serie: Annals of Medicine
ISSN: 0785-3890
DOI: https://doi.org/10.1080/07853890.2018.1564357
Permanenta länken (URI): http://hdl.handle.net/10138/326373
Abstrakt: Background: Seasonal variation in glucose metabolism might be driven by changes in daylight. Melatonin entrains circadian regulation and is directly associated with daylight. The relationship between melatonin receptor 1B gene variants with glycemic traits and type 2 diabetes is well established. We studied if daylight length was associated with glycemic traits and if it modified the relationship between melatonin receptor 1B gene rs10830963 variant and glycemic traits. Materials: A population-based sample of 3422 18-78-year-old individuals without diabetes underwent an oral glucose tolerance test twice, an average 6.8 years (SD = 0.9) apart and were genotyped for rs10830963. Daylight data was obtained from the Finnish Meteorological Institute. Results: Cross-sectionally, more daylight was associated with lower fasting glucose, but worse insulin sensitivity and secretion at follow-up. Longitudinally, individuals studied on lighter days at follow-up than at baseline showed higher glucose values during the oral glucose tolerance test and lower Corrected Insulin Response at follow-up. GG genotype carriers in the rs10830963 became more insulin resistant during follow-up if daylight length was shorter at follow-up than at baseline. Conclusions: Our study shows that individual glycemic profiles may vary according to daylight, MTNR1B genotype and their interaction. Future studies may consider taking daylight length into account.Key messages In Western Finland, the amount daylight follows an extensive annual variation ranging from 4 h 44 min to 20 h 17 min, making it ideal to study the associations between daylight and glycemic traits. Moreover, this allows researchers to explore if the relationship between the melatonin receptor 1B gene rs10830963 variant and glycemic traits is modified by the amount of daylight both cross-sectionally and longitudinally. This study shows that individuals, who participated in the study on lighter days at the follow-up than at the baseline, displayed to a greater extent worse glycemic profiles across the follow-up. Novel findings from the current study show that in the longitudinal analyses, each addition of the minor G allele of the melatonin receptor 1B gene rs10830963 was associated with worsening of fasting glucose values and insulin secretion across the 6.8-year follow-up. Importantly, this study shows that in those with the rs10830963 GG genotype, insulin sensitivity deteriorated the most significantly across the 6.8-year follow-up if the daylight length on the oral glucose tolerance testing date at the follow-up was shorter than at the baseline. Taken together, the current findings suggest that the amount of daylight may affect glycemic traits, especially fasting glucose and insulin secretion even though the effect size is small. The association can very according to the rs10830963 risk variant. Further research is needed to elucidate the mechanisms behind these associations.
Subject: Diabetes
glycemic traits
insulin sensitivity and resistance
melatonin
MTNR1B
daylight
seasonality
BETA-CELL FUNCTION
FASTING PLASMA-GLUCOSE
INSULIN-RESISTANCE
SEASONAL-VARIATION
DIABETES-MELLITUS
SHIFT WORK
SECRETION
RISK
SENSITIVITY
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by_nc
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion


Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
Haljas_08122018.pdf 258.8Kb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post