The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study

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dc.contributor.author Haljas, Kadri
dc.contributor.author Hakaste, Liisa
dc.contributor.author Lahti, Jari
dc.contributor.author Isomaa, Bo
dc.contributor.author Groop, Leif
dc.contributor.author Tuomi, Tiinamaija
dc.contributor.author Räikkönen, Katri
dc.date.accessioned 2021-02-12T07:38:04Z
dc.date.available 2021-02-12T07:38:04Z
dc.date.issued 2019-01-02
dc.identifier.citation Haljas , K , Hakaste , L , Lahti , J , Isomaa , B , Groop , L , Tuomi , T & Räikkönen , K 2019 , ' The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study ' , Annals of Medicine , vol. 51 , no. 1 , pp. 58-67 . https://doi.org/10.1080/07853890.2018.1564357
dc.identifier.other PURE: 124374889
dc.identifier.other PURE UUID: 0b50466e-6732-4744-a08d-e520124948b8
dc.identifier.other WOS: 000463853500006
dc.identifier.other ORCID: /0000-0002-4310-5297/work/64322297
dc.identifier.other ORCID: /0000-0003-3124-3470/work/64323602
dc.identifier.other ORCID: /0000-0002-8306-6202/work/64323870
dc.identifier.uri http://hdl.handle.net/10138/326373
dc.description.abstract Background: Seasonal variation in glucose metabolism might be driven by changes in daylight. Melatonin entrains circadian regulation and is directly associated with daylight. The relationship between melatonin receptor 1B gene variants with glycemic traits and type 2 diabetes is well established. We studied if daylight length was associated with glycemic traits and if it modified the relationship between melatonin receptor 1B gene rs10830963 variant and glycemic traits. Materials: A population-based sample of 3422 18-78-year-old individuals without diabetes underwent an oral glucose tolerance test twice, an average 6.8 years (SD = 0.9) apart and were genotyped for rs10830963. Daylight data was obtained from the Finnish Meteorological Institute. Results: Cross-sectionally, more daylight was associated with lower fasting glucose, but worse insulin sensitivity and secretion at follow-up. Longitudinally, individuals studied on lighter days at follow-up than at baseline showed higher glucose values during the oral glucose tolerance test and lower Corrected Insulin Response at follow-up. GG genotype carriers in the rs10830963 became more insulin resistant during follow-up if daylight length was shorter at follow-up than at baseline. Conclusions: Our study shows that individual glycemic profiles may vary according to daylight, MTNR1B genotype and their interaction. Future studies may consider taking daylight length into account.Key messages In Western Finland, the amount daylight follows an extensive annual variation ranging from 4 h 44 min to 20 h 17 min, making it ideal to study the associations between daylight and glycemic traits. Moreover, this allows researchers to explore if the relationship between the melatonin receptor 1B gene rs10830963 variant and glycemic traits is modified by the amount of daylight both cross-sectionally and longitudinally. This study shows that individuals, who participated in the study on lighter days at the follow-up than at the baseline, displayed to a greater extent worse glycemic profiles across the follow-up. Novel findings from the current study show that in the longitudinal analyses, each addition of the minor G allele of the melatonin receptor 1B gene rs10830963 was associated with worsening of fasting glucose values and insulin secretion across the 6.8-year follow-up. Importantly, this study shows that in those with the rs10830963 GG genotype, insulin sensitivity deteriorated the most significantly across the 6.8-year follow-up if the daylight length on the oral glucose tolerance testing date at the follow-up was shorter than at the baseline. Taken together, the current findings suggest that the amount of daylight may affect glycemic traits, especially fasting glucose and insulin secretion even though the effect size is small. The association can very according to the rs10830963 risk variant. Further research is needed to elucidate the mechanisms behind these associations. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Annals of Medicine
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Diabetes
dc.subject glycemic traits
dc.subject insulin sensitivity and resistance
dc.subject melatonin
dc.subject MTNR1B
dc.subject daylight
dc.subject seasonality
dc.subject BETA-CELL FUNCTION
dc.subject FASTING PLASMA-GLUCOSE
dc.subject INSULIN-RESISTANCE
dc.subject SEASONAL-VARIATION
dc.subject DIABETES-MELLITUS
dc.subject SHIFT WORK
dc.subject SECRETION
dc.subject RISK
dc.subject SENSITIVITY
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Doctoral Programme in Cognition, Learning, Instruction and Communication
dc.contributor.organization Medicum
dc.contributor.organization Endokrinologian yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Helsinki Collegium for Advanced Studies
dc.contributor.organization University of Helsinki
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Developmental Psychology Research Group
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1080/07853890.2018.1564357
dc.relation.issn 0785-3890
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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