Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision

Show full item record



Permalink

http://hdl.handle.net/10138/326434

Citation

Smeds , L , Takeshita , D , Turunen , T , Tiihonen , J S , Westö , J , Martyniuk , N , Seppänen , A J & Ala-Laurila , P 2019 , ' Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision ' , Neuron , vol. 104 , no. 3 , pp. 576-+ . https://doi.org/10.1016/j.neuron.2019.08.005

Title: Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision
Author: Smeds, Lina; Takeshita, Daisuke; Turunen, Tuomas; Tiihonen, Jussi Samuli; Westö, Johan; Martyniuk, Nataliia; Seppänen, Aarni Juhani; Ala-Laurila, Petri
Contributor: University of Helsinki, Ala-Laurila Lab
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Ala-Laurila Lab
University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2019-11-06
Language: eng
Number of pages: 23
Belongs to series: Neuron
ISSN: 0896-6273
URI: http://hdl.handle.net/10138/326434
Abstract: All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mouse line allowed us to separate the two primary retinal outputs, ON and OFF pathways, carrying information about photon absorptions as increases and decreases in spiking, respectively. Wemeasured the sensitivity limit of rods and the most sensitive ON and OFF ganglion cells and correlated these results with visually guided behavior using markerless head and eye tracking. We show that behavior relies only on the ON pathway even when the OFF pathway would allow higher sensitivity. Paradoxically, behavior does not rely on the spike code with maximal information but instead relies on a decoding strategy based on increases in spiking.
Subject: ABSOLUTE THRESHOLD
CHANNELS
LIGHT
MECHANISMS
MOUSE EYE
NOISE
PHOTOTRANSDUCTION
RETINAL GANGLION-CELLS
VISUAL PIGMENT
3112 Neurosciences
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Paradoxical_Rul ... tivity_Limit_of_Vision.pdf 22.02Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record