Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation

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Gonda , Y , Namba , T & Hanashima , C 2020 , ' Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation ' , Frontiers in Cell and Developmental Biology , vol. 8 , 607415 . https://doi.org/10.3389/fcell.2020.607415

Title: Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation
Author: Gonda, Yuko; Namba, Takashi; Hanashima, Carina
Contributor: University of Helsinki, Neuroscience Center
Date: 2020-12-23
Language: eng
Number of pages: 14
Belongs to series: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
URI: http://hdl.handle.net/10138/326449
Abstract: The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and dendrite formation of neocortical neurons. Abnormalities in these steps lead to disruption of the cortical structure and circuit, and underly various neurodevelopmental diseases, including dyslexia and autism spectrum disorder (ASD). In this review, we focus on the axon guidance signaling Slit-Robo, and address the multifaceted roles of Slit-Robo signaling in neocortical development. Recent studies have clarified the roles of Slit-Robo signaling not only in axon guidance but also in progenitor cell proliferation and migration, and the maturation of neocortical neurons. We further discuss the etiology of neurodevelopmental diseases, which are caused by defects in Slit-Robo signaling during neocortical formation.
Subject: Robo
Slit
neocortex
migration
proliferation
dendrite
spine
axon guidance
AUTISM SPECTRUM DISORDER
RADIAL GLIAL-CELLS
F-BAR DOMAIN
NEURONAL MIGRATION
INTERNEURON MIGRATION
DEVELOPMENTAL DYSLEXIA
CORTICAL INTERNEURONS
EXPRESSION PATTERNS
ROUNDABOUT RECEPTOR
BIPOLAR TRANSITION
1184 Genetics, developmental biology, physiology
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