Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation

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dc.contributor.author Gonda, Yuko
dc.contributor.author Namba, Takashi
dc.contributor.author Hanashima, Carina
dc.date.accessioned 2021-02-15T09:53:01Z
dc.date.available 2021-02-15T09:53:01Z
dc.date.issued 2020-12-23
dc.identifier.citation Gonda , Y , Namba , T & Hanashima , C 2020 , ' Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation ' , Frontiers in Cell and Developmental Biology , vol. 8 , 607415 . https://doi.org/10.3389/fcell.2020.607415
dc.identifier.other PURE: 160369146
dc.identifier.other PURE UUID: 28c5bddb-73e4-4df5-924c-2c20391391f1
dc.identifier.other WOS: 000604930200001
dc.identifier.other ORCID: /0000-0003-4875-666X/work/89117986
dc.identifier.uri http://hdl.handle.net/10138/326449
dc.description.abstract The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and dendrite formation of neocortical neurons. Abnormalities in these steps lead to disruption of the cortical structure and circuit, and underly various neurodevelopmental diseases, including dyslexia and autism spectrum disorder (ASD). In this review, we focus on the axon guidance signaling Slit-Robo, and address the multifaceted roles of Slit-Robo signaling in neocortical development. Recent studies have clarified the roles of Slit-Robo signaling not only in axon guidance but also in progenitor cell proliferation and migration, and the maturation of neocortical neurons. We further discuss the etiology of neurodevelopmental diseases, which are caused by defects in Slit-Robo signaling during neocortical formation. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Frontiers in Cell and Developmental Biology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Robo
dc.subject Slit
dc.subject neocortex
dc.subject migration
dc.subject proliferation
dc.subject dendrite
dc.subject spine
dc.subject axon guidance
dc.subject AUTISM SPECTRUM DISORDER
dc.subject RADIAL GLIAL-CELLS
dc.subject F-BAR DOMAIN
dc.subject NEURONAL MIGRATION
dc.subject INTERNEURON MIGRATION
dc.subject DEVELOPMENTAL DYSLEXIA
dc.subject CORTICAL INTERNEURONS
dc.subject EXPRESSION PATTERNS
dc.subject ROUNDABOUT RECEPTOR
dc.subject BIPOLAR TRANSITION
dc.subject 1184 Genetics, developmental biology, physiology
dc.title Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation en
dc.type Review Article
dc.contributor.organization Neuroscience Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fcell.2020.607415
dc.relation.issn 2296-634X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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