Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents

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Zeller , M , Heylen , E , Damanka , S , Pietsch , C , Donato , C , Tamura , T , Kulkarni , R , Arora , R , Cunliffe , N , Maunula , L , Potgieter , C , Tamim , S , De Coster , S , Zhirakovskaya , E , Bdour , S , O'Shea , H , Kirkwood , C D , Seheri , M , Nyaga , M M , Mphahlele , J , Chitambar , S D , Dagan , R , Armah , G , Tikunova , N , Van Ranst , M & Matthijnssens , J 2015 , ' Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents ' , Molecular Biology and Evolution , vol. 32 , no. 8 , pp. 2060-2071 . https://doi.org/10.1093/molbev/msv088

Title: Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents
Author: Zeller, Mark; Heylen, Elisabeth; Damanka, Susan; Pietsch, Corinna; Donato, Celeste; Tamura, Tsutomu; Kulkarni, Ruta; Arora, Ritu; Cunliffe, Nigel; Maunula, Leena; Potgieter, Christiaan; Tamim, Sana; De Coster, Sarah; Zhirakovskaya, Elena; Bdour, Salwa; O'Shea, Helen; Kirkwood, Carl D.; Seheri, Mapaseka; Nyaga, Martin Monene; Mphahlele, Jeffrey; Chitambar, Shobha D.; Dagan, Ron; Armah, George; Tikunova, Nina; Van Ranst, Marc; Matthijnssens, Jelle
Contributor organization: Departments of Faculty of Veterinary Medicine
Food Hygiene and Environmental Health
Leena Maunula / Principal Investigator
Food and Environmental Virology Research Group
Date: 2015-08
Language: eng
Number of pages: 12
Belongs to series: Molecular Biology and Evolution
ISSN: 0737-4038
DOI: https://doi.org/10.1093/molbev/msv088
URI: http://hdl.handle.net/10138/326453
Abstract: The majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-) complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988-2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The time to the most recent common ancestor (TMRCA) of all OP354-like P[8] genes was estimated at 1987. However, most OP354-like P[8] strains were found in three main clusters with TMRCAs estimated between 1996 and 2001. The VP7 gene segment of OP354-like P[8] strains showed evidence of frequent reassortment, even in localized epidemics, suggesting that OP354-like P[8] genes behave in a similar manner on the evolutionary level as other P[8] subtypes. The results of this study suggest that OP354-like P[8] strains have been able to disperse globally in a relatively short time period. This, in combination with a relatively large genetic distance to other P[8] subtypes, might result in a lower vaccine effectiveness, underscoring the need for a continued surveillance of OP354-like P[8] strains, especially in countries where rotavirus vaccination programs are in place.
Subject: OP354-like P[8]
emerging viruses
413 Veterinary science
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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