Plant Stanol Esters Reduce LDL (Low-Density Lipoprotein) Aggregation by Altering LDL Surface Lipids The BLOOD FLOW Randomized Intervention Study

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Ruuth , M , Äikäs , L , Tigistu-Sahle , F , Käkelä , R , Lindholm , H , Simonen , P , Kovanen , P T , Gylling , H & Öörni , K 2020 , ' Plant Stanol Esters Reduce LDL (Low-Density Lipoprotein) Aggregation by Altering LDL Surface Lipids The BLOOD FLOW Randomized Intervention Study ' , Arteriosclerosis, Thrombosis, and Vascular Biology , vol. 40 , no. 9 , pp. 2310-2321 . https://doi.org/10.1161/ATVBAHA.120.314329

Title: Plant Stanol Esters Reduce LDL (Low-Density Lipoprotein) Aggregation by Altering LDL Surface Lipids The BLOOD FLOW Randomized Intervention Study
Author: Ruuth, Maija; Äikäs, Lauri; Tigistu-Sahle, Feven; Käkelä, Reijo; Lindholm, Harri; Simonen, Piia; Kovanen, Petri T.; Gylling, Helena; Öörni, Katariina
Other contributor: University of Helsinki, Medicum
University of Helsinki, Wihuri Research Institute
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, Wihuri Research Institute
University of Helsinki, University of Helsinki
University of Helsinki, Biosciences












Date: 2020-09
Language: eng
Number of pages: 12
Belongs to series: Arteriosclerosis, Thrombosis, and Vascular Biology
ISSN: 1079-5642
DOI: https://doi.org/10.1161/ATVBAHA.120.314329
URI: http://hdl.handle.net/10138/326484
Abstract: OBJECTIVE: Plant stanol ester supplementation (2-3 g plant stanols/d) reduces plasma LDL (low-density lipoprotein) cholesterol concentration by 9% to 12% and is, therefore, recommended as part of prevention and treatment of atherosclerotic cardiovascular disease. In addition to plasma LDL-cholesterol concentration, also qualitative properties of LDL particles can influence atherogenesis. However, the effect of plant stanol ester consumption on the proatherogenic properties of LDL has not been studied. APPROACH AND RESULTS: Study subjects (n=90) were randomized to consume either a plant stanol ester-enriched spread (3.0 g plant stanols/d) or the same spread without added plant stanol esters for 6 months. Blood samples were taken at baseline and after the intervention. The aggregation susceptibility of LDL particles was analyzed by inducing aggregation of isolated LDL and following aggregate formation. LDL lipidome was determined by mass spectrometry. Binding of serum lipoproteins to proteoglycans was measured using a microtiter well-based assay. LDL aggregation susceptibility was decreased in the plant stanol ester group, and the median aggregate size after incubation for 2 hours decreased from 1490 to 620 nm,P=0.001. Plant stanol ester-induced decrease in LDL aggregation was more extensive in participants having body mass index CONCLUSIONS: Consumption of plant stanol esters decreases the aggregation susceptibility of LDL particles by modifying LDL lipidome. The resulting improvement of LDL quality may be beneficial for cardiovascular health. REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01315964. GRAPHIC ABSTRACT: A graphic abstract is available for this article.
Subject: atherosclerosis
cardiovascular disease
cholesterol
lipidomics
lipoproteins
B-CONTAINING LIPOPROTEINS
PHOSPHOLIPASE A(2)
CHOLESTEROL ABSORPTION
INCREASED BINDING
APOLIPOPROTEIN-B
GROUP-V
SPHINGOMYELINASE
PARTICLES
RETENTION
ATHEROSCLEROSIS
3121 General medicine, internal medicine and other clinical medicine
1182 Biochemistry, cell and molecular biology
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