Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly

Show full item record



Permalink

http://hdl.handle.net/10138/326548

Citation

Vari , H , Roslund , M , Oikarinen , S , Nurminen , N , Puhakka , R , Parajuli , A , Grönroos , M , Siter , N , Laitinen , O , Hyöty , H , Rajaniemi , J , Rantalainen , A-L , Sinkkonen , A & The ADELE Research Group 2021 , ' Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly ' , Chemosphere , vol. 265 , 128965 . https://doi.org/10.1016/j.chemosphere.2020.128965

Title: Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly
Author: Vari, Heli; Roslund, Marja; Oikarinen, Sami; Nurminen, Noora; Puhakka, Riikka; Parajuli, Anirudra; Grönroos, Mira; Siter, Nathan; Laitinen, Olli; Hyöty, Heikki; Rajaniemi, Juho; Rantalainen, Anna-Lea; Sinkkonen, Aki; The ADELE Research Group
Other contributor: University of Helsinki, Ecosystems and Environment Research Programme
University of Helsinki, Ecosystems and Environment Research Programme
University of Helsinki, Ecosystems and Environment Research Programme
University of Helsinki, Ecosystems and Environment Research Programme
University of Helsinki, Ecosystems and Environment Research Programme
University of Helsinki, Ecosystems and Environment Research Programme




Date: 2021-02
Language: eng
Number of pages: 12
Belongs to series: Chemosphere
ISSN: 0045-6535
DOI: https://doi.org/10.1016/j.chemosphere.2020.128965
URI: http://hdl.handle.net/10138/326548
Abstract: There is evidence that polycyclic aromatic hydrocarbons (PAHs) and human gut microbiota are associated with the modulation of endocrine signaling pathways. Independently, studies have found associations between air pollution, land cover and commensal microbiota. We are the first to estimate the interaction between land cover categories associated with air pollution or purification, PAH levels and endocrine signaling predicted from gut metagenome among urban and rural populations. The study participants were elderly people (65-79 years); 30 lived in rural and 32 in urban areas. Semi-Permeable Membrane devices were utilized to measure air PAH concentrations as they simulate the process of bioconcentration in the fatty tissues. Land cover categories were estimated using CORINE database and geographic information system. Functional orthologues for peroxisome proliferator-activated receptor (PPAR) pathway in endocrine system were analyzed from gut bacterial metagenome with Kyoto Encyclopaedia of Genes and Genomes. High coverage of broad-leaved and mixed forests around the homes were associated with decreased PAH levels in ambient air, while gut functional orthologues for PPAR pathway increased along with these forest types. The difference between urban and rural PAH concentrations was not notable. However, some rural measurements were higher than the urban average, which was due to the use of heavy equipment on active farms. The provision of air purification by forests might be an important determining factor in the context of endocrine disruption potential of PAHs. Particularly broad-leaved forests around homes may reduce PAH levels in ambient air and balance pollution-induced disturbances within commensal gut microbiota. (C) 2020 The Author(s). Published by Elsevier Ltd.
Subject: AREAS
CANCER RISK
ENVIRONMENTS
EXPOSURE
Endocrine disruption
Gut bacteria
HEALTH
Land cover categories
PAH
PARTICULATE
POLLUTION
POLYCYCLIC AROMATIC-HYDROCARBONS
PPAR
Pollution
RISK ASSESSMENT
Urban/rural gradient
1172 Environmental sciences
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Vari_Associatio ... _gaseous_PAH_levels_in.pdf 1.218Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record