Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Show full item record



Permalink

http://hdl.handle.net/10138/326601

Citation

McGlinchey , A , Sinioja , T , Lamichhane , S , Sen , P , Bodin , J , Siljander , H , Dickens , A M , Geng , D , Carlsson , C , Duberg , D , Ilonen , J , Virtanen , S M , Dirven , H , Berntsen , H F , Zimmer , K , Nygaard , U C , Oresic , M , Knip , M & Hyötyläinen , T 2020 , ' Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes ' , Environment International , vol. 143 , 105935 . https://doi.org/10.1016/j.envint.2020.105935

Title: Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
Author: McGlinchey, Aidan; Sinioja, Tim; Lamichhane, Santosh; Sen, Partho; Bodin, Johanna; Siljander, Heli; Dickens, Alex M.; Geng, Dawei; Carlsson, Cecilia; Duberg, Daniel; Ilonen, Jorma; Virtanen, Suvi M.; Dirven, Hubert; Berntsen, Hanne Friis; Zimmer, Karin; Nygaard, Unni C.; Oresic, Matej; Knip, Mikael; Hyötyläinen, Tuulia
Other contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Children and Adolescents






Date: 2020-10
Language: eng
Number of pages: 14
Belongs to series: Environment International
ISSN: 0160-4120
DOI: https://doi.org/10.1016/j.envint.2020.105935
URI: http://hdl.handle.net/10138/326601
Abstract: In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
Subject: Bile acids
Lipidomics
Mass spectrometry
PFAS
Type 1 diabetes
PERSISTENT ORGANIC POLLUTANTS
PERFLUORINATED COMPOUNDS
ISLET AUTOIMMUNITY
GUT MICROBIOME
ACID
CHILDHOOD
DETERMINANTS
METABOLISM
TRENDS
1182 Biochemistry, cell and molecular biology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0160412020318900_main.pdf 2.532Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record