RET Receptor Tyrosine Kinase : Role in Neurodegeneration, Obesity, and Cancer

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Mahato , A K & Sidorova , Y A 2020 , ' RET Receptor Tyrosine Kinase : Role in Neurodegeneration, Obesity, and Cancer ' , International Journal of Molecular Sciences , vol. 21 , no. 19 , 7108 . https://doi.org/10.3390/ijms21197108

Title: RET Receptor Tyrosine Kinase : Role in Neurodegeneration, Obesity, and Cancer
Author: Mahato, Arun Kumar; Sidorova, Yulia A.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Divisions of Faculty of Pharmacy
Date: 2020-10
Language: eng
Number of pages: 21
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/326615
Abstract: Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiation, survival, migration, and metabolism. RET plays a pivotal role in the development of both peripheral and central nervous systems. RET is expressed from early stages of embryogenesis and remains expressed throughout all life stages. Mutations either activating or inhibiting RET result in several aggressive diseases, namely cancer and Hirschsprung disease. However, the physiological ligand-dependent activation of RET receptor is important for the survival and maintenance of several neuronal populations, appetite, and weight gain control, thus providing an opportunity for the development of disease-modifying therapeutics against neurodegeneration and obesity. In this review, we describe the structure of RET, its signaling, and its role in both normal conditions as well as in several disorders. We highlight the differences in the signaling and outcomes of constitutive and ligand-induced RET activation. Finally, we review the data on recently developed small molecular weight RET agonists and their potential for the treatment of various diseases.
Subject: rearranged in transfection (RET)
neurodegeneration
obesity
cancer
RET agonist
neurorestoration
retinitis pigmentosa
hirschsprung disease
glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs)
growth differentiation factor 15 (GDF15)
MIDBRAIN DOPAMINERGIC-NEURONS
NEUROTROPHIC FACTOR
GDNF FAMILY
PARKINSONS-DISEASE
LIPID RAFTS
C-RET
FUNCTIONAL RECOVERY
TRANSFORMING GENE
MESSENGER-RNAS
MULLER GLIA
1182 Biochemistry, cell and molecular biology
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