Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

Show full item record



Permalink

http://hdl.handle.net/10138/326663

Citation

Hemmila , S , Ruponen , M , Toropainen , E , Tengvall-Unadike , U , Urtti , A & Kallio , P 2020 , ' Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies ' , Slas technology , vol. 25 , no. 5 , pp. 455-462 . https://doi.org/10.1177/2472630320916190

Title: Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies
Author: Hemmila, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi
Contributor: University of Helsinki, University of Eastern Finland (UEF)
University of Helsinki, Drug Research Program
Date: 2020-10
Language: eng
Number of pages: 8
Belongs to series: Slas technology
ISSN: 2472-6303
URI: http://hdl.handle.net/10138/326663
Abstract: This paper presents a novel microflow-based concept for studying the permeability of in vitro cell models or ex vivo tissues. Using the proposed concept, we demonstrate how to maintain physiologically relevant test conditions and produce highly reproducible permeability values for a range (31) of drug compounds. The apparent permeability coefficients (P-app) showed excellent correlation (0.89) with the values from experiments performed with a conventional Ussing chamber. Additionally, the microflow-based concept produces notably more concentrated samples than the conventional Ussing chamber-based approach, despite the fact that more than 10 times smaller quantities of test compounds and biological membranes are needed in the microflow-based concept.
Subject: permeability
in vitro
ex vivo
microfluidics
PREDICTION
ABSORPTION
PDMS
IMPACT
CELLS
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
2472630320916190.pdf 1.177Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record