Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

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http://hdl.handle.net/10138/326663

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Hemmila , S , Ruponen , M , Toropainen , E , Tengvall-Unadike , U , Urtti , A & Kallio , P 2020 , ' Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies ' , Slas technology , vol. 25 , no. 5 , pp. 455-462 . https://doi.org/10.1177/2472630320916190

Titel: Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies
Författare: Hemmila, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi
Upphovmannens organisation: Drug Research Program
Drug Delivery
Drug Delivery Unit
Division of Pharmaceutical Biosciences
Datum: 2020-10
Språk: eng
Sidantal: 8
Tillhör serie: Slas technology
ISSN: 2472-6303
DOI: https://doi.org/10.1177/2472630320916190
Permanenta länken (URI): http://hdl.handle.net/10138/326663
Abstrakt: This paper presents a novel microflow-based concept for studying the permeability of in vitro cell models or ex vivo tissues. Using the proposed concept, we demonstrate how to maintain physiologically relevant test conditions and produce highly reproducible permeability values for a range (31) of drug compounds. The apparent permeability coefficients (P-app) showed excellent correlation (0.89) with the values from experiments performed with a conventional Ussing chamber. Additionally, the microflow-based concept produces notably more concentrated samples than the conventional Ussing chamber-based approach, despite the fact that more than 10 times smaller quantities of test compounds and biological membranes are needed in the microflow-based concept.
Subject: permeability
in vitro
ex vivo
microfluidics
PREDICTION
ABSORPTION
PDMS
IMPACT
CELLS
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
317 Pharmacy
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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