Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

Show simple item record

dc.contributor.author Hemmila, Samu
dc.contributor.author Ruponen, Marika
dc.contributor.author Toropainen, Elisa
dc.contributor.author Tengvall-Unadike, Unni
dc.contributor.author Urtti, Arto
dc.contributor.author Kallio, Pasi
dc.date.accessioned 2021-02-17T14:45:01Z
dc.date.available 2021-02-17T14:45:01Z
dc.date.issued 2020-10
dc.identifier.citation Hemmila , S , Ruponen , M , Toropainen , E , Tengvall-Unadike , U , Urtti , A & Kallio , P 2020 , ' Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies ' , Slas technology , vol. 25 , no. 5 , pp. 455-462 . https://doi.org/10.1177/2472630320916190
dc.identifier.other PURE: 141352482
dc.identifier.other PURE UUID: 8b9cdeec-a3f4-43b6-b822-6815213ba28d
dc.identifier.other WOS: 000533111100001
dc.identifier.uri http://hdl.handle.net/10138/326663
dc.description.abstract This paper presents a novel microflow-based concept for studying the permeability of in vitro cell models or ex vivo tissues. Using the proposed concept, we demonstrate how to maintain physiologically relevant test conditions and produce highly reproducible permeability values for a range (31) of drug compounds. The apparent permeability coefficients (P-app) showed excellent correlation (0.89) with the values from experiments performed with a conventional Ussing chamber. Additionally, the microflow-based concept produces notably more concentrated samples than the conventional Ussing chamber-based approach, despite the fact that more than 10 times smaller quantities of test compounds and biological membranes are needed in the microflow-based concept. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Slas technology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject permeability
dc.subject in vitro
dc.subject ex vivo
dc.subject microfluidics
dc.subject PREDICTION
dc.subject ABSORPTION
dc.subject PDMS
dc.subject IMPACT
dc.subject CELLS
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 116 Chemical sciences
dc.subject 317 Pharmacy
dc.title Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies en
dc.type Article
dc.contributor.organization Drug Research Program
dc.contributor.organization Drug Delivery
dc.contributor.organization Drug Delivery Unit
dc.contributor.organization Division of Pharmaceutical Biosciences
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1177/2472630320916190
dc.relation.issn 2472-6303
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
2472630320916190.pdf 1.177Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record