Setting a baseline for global urban virome surveillance in sewage

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Global Sewage Surveillance project consortium , Nieuwenhuijse , D F , Munnink , B B O , Phan , M V T , Munk , P , Venkatakrishnan , S , Aarestrup , F M , Cotten , M , Koopmans , M P G , Heikinheimo , A & Berzins , A 2020 , ' Setting a baseline for global urban virome surveillance in sewage ' , Scientific Reports , vol. 10 , no. 1 , 13748 . https://doi.org/10.1038/s41598-020-69869-0

Title: Setting a baseline for global urban virome surveillance in sewage
Author: Global Sewage Surveillance Project; Nieuwenhuijse, David F.; Munnink, Bas B. Oude; Phan, My V. T.; Munk, Patrick; Venkatakrishnan, Shweta; Aarestrup, Frank M.; Cotten, Matthew; Koopmans, Marion P. G.; Heikinheimo, Annamari; Berzins, Aivars
Other contributor: University of Helsinki, University of Helsinki
University of Helsinki, Food Hygiene and Environmental Health



Date: 2020-08-13
Language: eng
Number of pages: 13
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-020-69869-0
URI: http://hdl.handle.net/10138/326696
Abstract: The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.
Subject: VIRUSES
CLASSIFICATION
ENTEROVIRUSES
CORONAVIRUS
SEASONALITY
POLIOVIRUS
PATTERNS
11832 Microbiology and virology
3142 Public health care science, environmental and occupational health
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