Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons

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EuroSIDA study , Mocroft , A , Lundgren , J D , Rockstroh , J K , Aho , I & Peters , L 2020 , ' Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons ' , Open Forum Infectious Diseases , vol. 7 , no. 12 , 470 . https://doi.org/10.1093/ofid/ofaa470

Title: Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons
Author: EuroSIDA study; Mocroft, Amanda; Lundgren, Jens D.; Rockstroh, Juergen K.; Aho, Inka; Peters, Lars
Other contributor: University of Helsinki, HUS Internal Medicine and Rehabilitation

Date: 2020-12
Language: eng
Number of pages: 10
Belongs to series: Open Forum Infectious Diseases
ISSN: 2328-8957
DOI: https://doi.org/10.1093/ofid/ofaa470
URI: http://hdl.handle.net/10138/326761
Abstract: Background. The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear. Methods. Poisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (antiHCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment). Results. A total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNApositive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6-13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7-8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P = .33). Hypertension (22.2%; 95% CI, 17.5%-26.2%) and body mass index >25 (22.0%; 95% CI, 10.4%-29.7%) had the largest population-attributable fractions for DM. Conclusions. HCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.
Subject: diabetes mellitus
direct-acting antivirals
hepatitis C
HIV
sustained virologic response
VIRUS-INFECTION
EXTRAHEPATIC MANIFESTATIONS
PREVALENCE
MORTALITY
EVENTS
DEATH
ERA
3121 General medicine, internal medicine and other clinical medicine
11832 Microbiology and virology
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