Effects of Environmental Factors on Severity and Mortality of COVID-19

Näytä kaikki kuvailutiedot



Pysyväisosoite

http://hdl.handle.net/10138/326775

Lähdeviite

Kifer , D , Bugada , D , Villar-Garcia , J , Gudelj , I , Menni , C , Sudre , C , Vuckovic , F , Ugrina , I , Lorini , L F , Posso , M , Bettinelli , S , Ughi , N , Maloberti , A , Epis , O , Giannattasio , C , Rossetti , C , Kalogjera , L , Persec , J , Ollivere , L , Ollivere , B J , Yan , H , Cai , T , Aithal , G P , Steves , C J , Kantele , A , Kajova , M , Vapalahti , O , Sajantila , A , Wojtowicz , R , Wierzba , W , Krol , Z , Zaczynski , A , Zycinska , K , Postula , M , Luksic , I , Civljak , R , Markotic , A , Brachmann , J , Markl , A , Mahnkopf , C , Murray , B , Ourselin , S , Valdes , A M , Horcajada , J P , Castells , X , Pascual , J , Allegri , M , Primorac , D , Spector , T D , Barrios , C & Lauc , G 2021 , ' Effects of Environmental Factors on Severity and Mortality of COVID-19 ' , Frontiers in Medicine , vol. 7 , 607786 . https://doi.org/10.3389/fmed.2020.607786

Julkaisun nimi: Effects of Environmental Factors on Severity and Mortality of COVID-19
Tekijä: Kifer, Domagoj; Bugada, Dario; Villar-Garcia, Judit; Gudelj, Ivan; Menni, Cristina; Sudre, Carole; Vuckovic, Frano; Ugrina, Ivo; Lorini, Luca F.; Posso, Margarita; Bettinelli, Silvia; Ughi, Nicola; Maloberti, Alessandro; Epis, Oscar; Giannattasio, Cristina; Rossetti, Claudio; Kalogjera, Livije; Persec, Jasminka; Ollivere, Luke; Ollivere, Benjamin J.; Yan, Huadong; Cai, Ting; Aithal, Guruprasad P.; Steves, Claire J.; Kantele, Anu; Kajova, Mikael; Vapalahti, Olli; Sajantila, Antti; Wojtowicz, Rafal; Wierzba, Waldemar; Krol, Zbigniew; Zaczynski, Artur; Zycinska, Katarina; Postula, Marek; Luksic, Ivica; Civljak, Rok; Markotic, Alemka; Brachmann, Johannes; Markl, Andreas; Mahnkopf, Christian; Murray, Benjamin; Ourselin, Sebastien; Valdes, Ana M.; Horcajada, Juan P.; Castells, Xavier; Pascual, Julio; Allegri, Massimo; Primorac, Dragan; Spector, Tim D.; Barrios, Clara; Lauc, Gordan
Tekijän organisaatio: Department of Medicine
HUS Inflammation Center
Department of Virology
Veterinary Biosciences
Helsinki One Health (HOH)
Olli Pekka Vapalahti / Principal Investigator
Viral Zoonosis Research Unit
Veterinary Microbiology and Epidemiology
HUSLAB
Department of Forensic Medicine
Päiväys: 2021-01-20
Kieli: eng
Sivumäärä: 10
Kuuluu julkaisusarjaan: Frontiers in Medicine
ISSN: 2296-858X
DOI-tunniste: https://doi.org/10.3389/fmed.2020.607786
URI: http://hdl.handle.net/10138/326775
Tiivistelmä: Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973-0.988, p <0.001) and per increase in ambient temperature of 1 degrees C to be 0.854 (0.773-0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.
Avainsanat: COVID-19
seasonality
mortality
mucins
humidity
3111 Biomedicine
3142 Public health care science, environmental and occupational health
11832 Microbiology and virology
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
fmed_07_607786.pdf 1.169MB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot