Effects of Environmental Factors on Severity and Mortality of COVID-19

Show simple item record

dc.contributor.author Kifer, Domagoj
dc.contributor.author Bugada, Dario
dc.contributor.author Villar-Garcia, Judit
dc.contributor.author Gudelj, Ivan
dc.contributor.author Menni, Cristina
dc.contributor.author Sudre, Carole
dc.contributor.author Vuckovic, Frano
dc.contributor.author Ugrina, Ivo
dc.contributor.author Lorini, Luca F.
dc.contributor.author Posso, Margarita
dc.contributor.author Bettinelli, Silvia
dc.contributor.author Ughi, Nicola
dc.contributor.author Maloberti, Alessandro
dc.contributor.author Epis, Oscar
dc.contributor.author Giannattasio, Cristina
dc.contributor.author Rossetti, Claudio
dc.contributor.author Kalogjera, Livije
dc.contributor.author Persec, Jasminka
dc.contributor.author Ollivere, Luke
dc.contributor.author Ollivere, Benjamin J.
dc.contributor.author Yan, Huadong
dc.contributor.author Cai, Ting
dc.contributor.author Aithal, Guruprasad P.
dc.contributor.author Steves, Claire J.
dc.contributor.author Kantele, Anu
dc.contributor.author Kajova, Mikael
dc.contributor.author Vapalahti, Olli
dc.contributor.author Sajantila, Antti
dc.contributor.author Wojtowicz, Rafal
dc.contributor.author Wierzba, Waldemar
dc.contributor.author Krol, Zbigniew
dc.contributor.author Zaczynski, Artur
dc.contributor.author Zycinska, Katarina
dc.contributor.author Postula, Marek
dc.contributor.author Luksic, Ivica
dc.contributor.author Civljak, Rok
dc.contributor.author Markotic, Alemka
dc.contributor.author Brachmann, Johannes
dc.contributor.author Markl, Andreas
dc.contributor.author Mahnkopf, Christian
dc.contributor.author Murray, Benjamin
dc.contributor.author Ourselin, Sebastien
dc.contributor.author Valdes, Ana M.
dc.contributor.author Horcajada, Juan P.
dc.contributor.author Castells, Xavier
dc.contributor.author Pascual, Julio
dc.contributor.author Allegri, Massimo
dc.contributor.author Primorac, Dragan
dc.contributor.author Spector, Tim D.
dc.contributor.author Barrios, Clara
dc.contributor.author Lauc, Gordan
dc.date.accessioned 2021-02-19T10:52:01Z
dc.date.available 2021-02-19T10:52:01Z
dc.date.issued 2021-01-20
dc.identifier.citation Kifer , D , Bugada , D , Villar-Garcia , J , Gudelj , I , Menni , C , Sudre , C , Vuckovic , F , Ugrina , I , Lorini , L F , Posso , M , Bettinelli , S , Ughi , N , Maloberti , A , Epis , O , Giannattasio , C , Rossetti , C , Kalogjera , L , Persec , J , Ollivere , L , Ollivere , B J , Yan , H , Cai , T , Aithal , G P , Steves , C J , Kantele , A , Kajova , M , Vapalahti , O , Sajantila , A , Wojtowicz , R , Wierzba , W , Krol , Z , Zaczynski , A , Zycinska , K , Postula , M , Luksic , I , Civljak , R , Markotic , A , Brachmann , J , Markl , A , Mahnkopf , C , Murray , B , Ourselin , S , Valdes , A M , Horcajada , J P , Castells , X , Pascual , J , Allegri , M , Primorac , D , Spector , T D , Barrios , C & Lauc , G 2021 , ' Effects of Environmental Factors on Severity and Mortality of COVID-19 ' , Frontiers in Medicine , vol. 7 , 607786 . https://doi.org/10.3389/fmed.2020.607786
dc.identifier.other PURE: 160506947
dc.identifier.other PURE UUID: c99f1d31-44d1-4756-83f4-a1e63e7bbf3f
dc.identifier.other WOS: 000614084300001
dc.identifier.other ORCID: /0000-0003-2270-6824/work/89115110
dc.identifier.uri http://hdl.handle.net/10138/326775
dc.description.abstract Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973-0.988, p <0.001) and per increase in ambient temperature of 1 degrees C to be 0.854 (0.773-0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Frontiers in Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject COVID-19
dc.subject seasonality
dc.subject mortality
dc.subject mucins
dc.subject humidity
dc.subject 3111 Biomedicine
dc.subject 3142 Public health care science, environmental and occupational health
dc.subject 11832 Microbiology and virology
dc.title Effects of Environmental Factors on Severity and Mortality of COVID-19 en
dc.type Article
dc.contributor.organization Department of Medicine
dc.contributor.organization HUS Inflammation Center
dc.contributor.organization Department of Virology
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Olli Pekka Vapalahti / Principal Investigator
dc.contributor.organization Viral Zoonosis Research Unit
dc.contributor.organization Veterinary Microbiology and Epidemiology
dc.contributor.organization HUSLAB
dc.contributor.organization Department of Forensic Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fmed.2020.607786
dc.relation.issn 2296-858X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
fmed_07_607786.pdf 1.169Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record