Maternal depression and inflammation during pregnancy

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Lahti-Pulkkinen , M , Girchenko , P , Robinson , R , Lehto , S M , Toffol , E , Heinonen , K , Reynolds , R M , Kajantie , E , Laivuori , H , Villa , P M , Hamalainen , E , Lahti , J & Raikkonen , K 2020 , ' Maternal depression and inflammation during pregnancy ' , Psychological Medicine , vol. 50 , no. 11 , 0033291719001909 , pp. 1839-1851 . https://doi.org/10.1017/S0033291719001909

Title: Maternal depression and inflammation during pregnancy
Author: Lahti-Pulkkinen, Marius; Girchenko, Polina; Robinson, Rachel; Lehto, Soili M.; Toffol, Elena; Heinonen, Kati; Reynolds, Rebecca M.; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M.; Hamalainen, Esa; Lahti, Jari; Raikkonen, Katri
Contributor: University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Developmental Psychology Research Group
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Medicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
Date: 2020-08
Language: eng
Number of pages: 13
Belongs to series: Psychological Medicine
ISSN: 0033-2917
URI: http://hdl.handle.net/10138/326897
Abstract: Background Maternal depression during pregnancy increases the risk for adverse developmental outcomes in children. However, the underpinning biological mechanisms remain unknown. We tested whether depression was associated with levels of and change in the inflammatory state during pregnancy, if early pregnancy overweight/obesity or diabetes/hypertensive pregnancy disorders accounted for/mediated these effects, and if depression added to the inflammation that typically accompanies these conditions. Methods We analyzed plasma high-sensitivity C-reactive protein (hsCRP) and glycoprotein acetyls at three consecutive stages during pregnancy, derived history of depression diagnoses before pregnancy from Care Register for Healthcare (HILMO) (N= 375) and self-reports (N= 347) and depressive symptoms during pregnancy using the Center for Epidemiological Studies Depression Scale completed concurrently to blood samplings (N= 295). Data on early pregnancy body mass index (BMI) and diabetes/hypertensive pregnancy disorders came from medical records. Results Higher overall hsCRP levels, but not change, during pregnancy were predicted by history of depression diagnosis before pregnancy [HILMO: mean difference (MD) = 0.69 standard deviation (s.d.) units; 95% confidence interval (CI) 0.26-1.11, self-report: MD = 0.56s.d.; 95% CI 0.17-0.94] and higher depressive symptoms during pregnancy (0.06s.d.pers.d.increase; 95% CI 0.00-0.13). History of depression diagnosis before pregnancy also predicted higher overall glycoprotein acetyls (HILMO: MD = 0.52s.d.; 95% CI 0.12-0.93). These associations were not explained by diabetes/hypertensive disorders, but were accounted for and mediated by early pregnancy BMI. Furthermore, in obese women, overall hsCRP levels increased as depressive symptoms during pregnancy increased (p= 0.006 for interaction). Conclusions Depression is associated with a proinflammatory state during pregnancy. These associations are mediated by early pregnancy BMI, and depressive symptoms during pregnancy aggravate the inflammation related to obesity.
Subject: Antenatal
depression
depressive disorder
depressive symptoms
fetal programming
glycoprotein
hsCRP
inflammation
C-REACTIVE PROTEIN
MOOD DISORDERS
ALL-CAUSE
SYMPTOMS
OBESITY
CRP
METAANALYSIS
ASSOCIATION
RISK
PREVALENCE
515 Psychology
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