Transglutaminases and Obesity in Humans : Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response

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Kaartinen , M T , Arora , M , Heinonen , S , Rissanen , A , Kaprio , J & Pietiläinen , K H 2020 , ' Transglutaminases and Obesity in Humans : Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response ' , International Journal of Molecular Sciences , vol. 21 , no. 21 , 8289 . https://doi.org/10.3390/ijms21218289

Title: Transglutaminases and Obesity in Humans : Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
Author: Kaartinen, Mari T.; Arora, Mansi; Heinonen, Sini; Rissanen, Aila; Kaprio, Jaakko; Pietiläinen, Kirsi H.
Contributor: University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, HUS Psychiatry
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Abdominal Center
Date: 2020-11
Language: eng
Number of pages: 20
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/326949
Abstract: Transglutaminases TG2 and FXIII-A have recently been linked to adipose tissue biology and obesity, however, human studies for TG family members in adipocytes have not been conducted. In this study, we investigated the association of TGM family members to acquired weight gain in a rare set of monozygotic (MZ) twins discordant for body weight, i.e., heavy-lean twin pairs. We report that F13A1 is the only TGM family member showing significantly altered, higher expression in adipose tissue of the heavier twin. Our previous work linked adipocyte F13A1 to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. Here, we explored further the link of F13A1 to adipocyte size in the MZ twins via a previously conducted TWA study that was further mined for genes that specifically associate to hypertrophic adipocytes. We report that differential expression of F13A1 (Delta Heavy-Lean) associated with 47 genes which were linked via gene enrichment analysis to immune response, leucocyte and neutrophil activation, as well as cytokine response and signaling. Our work brings further support to the role of F13A1 in the human adipose tissue pathology, suggesting a role in the cascade that links hypertrophic adipocytes with inflammation.
Subject: Factor XIII-A
F131A
obesity
weight gain
adipocyte size
inflammation
FACTOR XIII-A
METABOLICALLY HEALTHY OBESITY
DIET-INDUCED OBESITY
PLASMA FIBRONECTIN
CELL-SIZE
TYROSINE-PHOSPHATASE
INSULIN-RESISTANCE
COAGULATION-FACTOR
ENDOTHELIAL-CELLS
CROSS-LINKING
1182 Biochemistry, cell and molecular biology
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