Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study
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Ala-Mutka , E M , Rimpelä , J M , Fyhrquist , F , Kontula , K K & Hiltunen , T P 2018 , ' Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study ' , Pharmacogenomics , vol. 19 , no. 6 , pp. 517-527 . https://doi.org/10.2217/pgs-2017-0184
| Title: | Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study |
| Author: | Ala-Mutka, Eero M.; Rimpelä, Jenni M.; Fyhrquist, Frej; Kontula, Kimmo K.; Hiltunen, Timo P. |
| Contributor organization: | Clinicum University of Helsinki Department of Medicine Kimmo Kontula Research Group HUS Internal Medicine and Rehabilitation |
| Date: | 2018-04 |
| Language: | eng |
| Number of pages: | 11 |
| Belongs to series: | Pharmacogenomics |
| ISSN: | 1462-2416 |
| DOI: | https://doi.org/10.2217/pgs-2017-0184 |
| URI: | http://hdl.handle.net/10138/326994 |
| Abstract: | Aim: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration. Patients & methods: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from the GENRES study. Replication analyses were performed in 465 Finns from the LIFE study. Results: In GENRES, we identified 31 loci associated with hydrochlorothiazide-induced change in SUA at p <5 x 10(-5). rs1002976 near VEGFC associated with the change in GENRES and in LIFE. rs950569 near BRINP3 associated with the change in SUA in GENRES and LIFE. The analysis of previously reported SNPs and candidate genes provided some proof for PADI4 and ABCC4. Conclusion: We report genetic markers that may predict the increase in SUA concentration during thiazide treatment. |
| Subject: |
hydrochlorothiazide
pharmacogenomics uric acid GROWTH-FACTOR 23 ANTIHYPERTENSIVE DRUG RESPONSES CHRONIC KIDNEY-DISEASE HYPERURICEMIA LIFE TRANSPORTER REDUCTION MORTALITY EXCRETION OUTCOMES 317 Pharmacy |
| Peer reviewed: | Yes |
| Usage restriction: | openAccess |
| Self-archived version: | acceptedVersion |
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