Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study

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http://hdl.handle.net/10138/326994

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Ala-Mutka , E M , Rimpelä , J M , Fyhrquist , F , Kontula , K K & Hiltunen , T P 2018 , ' Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study ' , Pharmacogenomics , vol. 19 , no. 6 , pp. 517-527 . https://doi.org/10.2217/pgs-2017-0184

Title: Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study
Author: Ala-Mutka, Eero M.; Rimpelä, Jenni M.; Fyhrquist, Frej; Kontula, Kimmo K.; Hiltunen, Timo P.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
University of Helsinki, Kimmo Kontula / Principal Investigator
Date: 2018-04
Language: eng
Number of pages: 11
Belongs to series: Pharmacogenomics
ISSN: 1462-2416
URI: http://hdl.handle.net/10138/326994
Abstract: Aim: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration. Patients & methods: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from the GENRES study. Replication analyses were performed in 465 Finns from the LIFE study. Results: In GENRES, we identified 31 loci associated with hydrochlorothiazide-induced change in SUA at p <5 x 10(-5). rs1002976 near VEGFC associated with the change in GENRES and in LIFE. rs950569 near BRINP3 associated with the change in SUA in GENRES and LIFE. The analysis of previously reported SNPs and candidate genes provided some proof for PADI4 and ABCC4. Conclusion: We report genetic markers that may predict the increase in SUA concentration during thiazide treatment.
Subject: hydrochlorothiazide
pharmacogenomics
uric acid
GROWTH-FACTOR 23
ANTIHYPERTENSIVE DRUG RESPONSES
CHRONIC KIDNEY-DISEASE
HYPERURICEMIA
LIFE
TRANSPORTER
REDUCTION
MORTALITY
EXCRETION
OUTCOMES
317 Pharmacy
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