Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis

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Keles Yucel , Z P , Silbereisen , A , Emingil , G , Tokgoz , Y , Kose , T , Sorsa , T , Tsilingaridis , G & Bostanci , N 2020 , ' Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis ' , Journal of Periodontology , vol. 91 , no. 10 , pp. 1339-1347 .

Title: Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis
Author: Keles Yucel, Zeynep Pinar; Silbereisen, Angelika; Emingil, Gulnur; Tokgoz, Yavuz; Kose, Timur; Sorsa, Timo; Tsilingaridis, Georgios; Bostanci, Nagihan
Contributor organization: HUS Head and Neck Center
Department of Oral and Maxillofacial Diseases
Suu- ja leukakirurgian yksikkö
University of Helsinki
Helsinki University Hospital Area
Date: 2020-10
Language: eng
Number of pages: 9
Belongs to series: Journal of Periodontology
ISSN: 0022-3492
Abstract: Abstract Background Cystic fibrosis (CF) is a life-threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as reservoir of bacterial colonization and potentially reflect systemic inflammation. This study investigated whether salivary triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1), interleukin (IL)-1? and calprotectin are associated with CF or reflect concomitant gingival inflammation. Methods Ten CF (age:3-12yrs) and ten systemically healthy age-and-gender-matched children (C) were enrolled in the study. Individuals with CF underwent routine laboratory determinations. Probing pocket depth (PPD), gingival index (GI), plaque index (PI) and bleeding on probing (BOP) were recorded on fully erupted teeth and saliva samples collected. Salivary TREM-1, PGLYRP1, IL-1? and calprotectin were analysed by ELISA. Results Children with CF had significantly higher BOP scores (P = 0.001) and calprotectin levels (P = 0.017) compared to the C group. TREM-1, PGLYRP1 and IL-1? could not distinguish between CF and SH but showed positive correlation with GI, PI and BOP in both groups. Calprotectin levels positively correlated with procalcitonin (P = 0.014), thrombocyte counts (P = 0.001), mean platelet volume (P = 0.030) and with PGLYRP1 (P = 0.019) and IL-1? (P = 0.013) in CF children. Receiver operating characteristic curve analysis for calprotectin (CFvsC) showed an area under the curve of 0.79 (95% CI 0.58-0.99, P = 0.034). Conclusions CF children presented with higher gingival inflammation scores and salivary calprotectin levels, that correlated with systemic inflammatory markers. Salivary calprotectin levels were not associated with periodontal parameters. Hence, preliminary data demonstrate that salivary calprotectin might have a chairside diagnostic potential for CF in children. This article is protected by copyright. All rights reserved
Subject: biomarkers
cystic fibrosis
TREM-1 protein
313 Dentistry
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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