Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis

Show simple item record Keles Yucel, Zeynep Pinar Silbereisen, Angelika Emingil, Gulnur Tokgoz, Yavuz Kose, Timur Sorsa, Timo Tsilingaridis, Georgios Bostanci, Nagihan 2021-02-24T22:57:58Z 2021-12-18T03:45:49Z 2020-10
dc.identifier.citation Keles Yucel , Z P , Silbereisen , A , Emingil , G , Tokgoz , Y , Kose , T , Sorsa , T , Tsilingaridis , G & Bostanci , N 2020 , ' Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis ' , Journal of Periodontology , vol. 91 , no. 10 , pp. 1339-1347 .
dc.identifier.other PURE: 132847002
dc.identifier.other PURE UUID: ea98a9d1-ebf8-4534-82cc-bfd9ebc82713
dc.identifier.other RIS: urn:61D59BF00A96450D203C28A98263BB19
dc.identifier.other WOS: 000526682500001
dc.description.abstract Abstract Background Cystic fibrosis (CF) is a life-threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as reservoir of bacterial colonization and potentially reflect systemic inflammation. This study investigated whether salivary triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1), interleukin (IL)-1? and calprotectin are associated with CF or reflect concomitant gingival inflammation. Methods Ten CF (age:3-12yrs) and ten systemically healthy age-and-gender-matched children (C) were enrolled in the study. Individuals with CF underwent routine laboratory determinations. Probing pocket depth (PPD), gingival index (GI), plaque index (PI) and bleeding on probing (BOP) were recorded on fully erupted teeth and saliva samples collected. Salivary TREM-1, PGLYRP1, IL-1? and calprotectin were analysed by ELISA. Results Children with CF had significantly higher BOP scores (P = 0.001) and calprotectin levels (P = 0.017) compared to the C group. TREM-1, PGLYRP1 and IL-1? could not distinguish between CF and SH but showed positive correlation with GI, PI and BOP in both groups. Calprotectin levels positively correlated with procalcitonin (P = 0.014), thrombocyte counts (P = 0.001), mean platelet volume (P = 0.030) and with PGLYRP1 (P = 0.019) and IL-1? (P = 0.013) in CF children. Receiver operating characteristic curve analysis for calprotectin (CFvsC) showed an area under the curve of 0.79 (95% CI 0.58-0.99, P = 0.034). Conclusions CF children presented with higher gingival inflammation scores and salivary calprotectin levels, that correlated with systemic inflammatory markers. Salivary calprotectin levels were not associated with periodontal parameters. Hence, preliminary data demonstrate that salivary calprotectin might have a chairside diagnostic potential for CF in children. This article is protected by copyright. All rights reserved en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Journal of Periodontology
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject biomarkers
dc.subject calprotectin
dc.subject cystic fibrosis
dc.subject gingivitis
dc.subject saliva
dc.subject TREM-1 protein
dc.subject ORAL-HEALTH
dc.subject MARKERS
dc.subject PGLYRP1
dc.subject STREM-1
dc.subject 313 Dentistry
dc.title Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis en
dc.type Article
dc.contributor.organization HUS Head and Neck Center
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.contributor.organization Suu- ja leukakirurgian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0022-3492
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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