Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex

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Meyer-Frießem , CH , Attal , N , Baron , R , Bouhassira , D , Finnerup , NB , Freynhagen , R , Gierthmühlen , J , Haanpää , M , Hansson , P , Jensen , TS , Kemp , H , Kennedy , D , Leffler , A-S , Rice , ASC , Segerdahl , M , Serra , J , Sindrup , S , Solà , R , Tölle , T , Schuh-Hofer , S , Treede , R-D , Pogatzki-Zahn , E , Maier , C & Vollert , J 2020 , ' Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex ' , European Journal of Pain , vol. 24 , no. 6 , pp. 1058-1071 .

Title: Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex
Author: Meyer-Frießem, CH; Attal, N; Baron, R; Bouhassira, D; Finnerup, NB; Freynhagen, R; Gierthmühlen, J; Haanpää, M; Hansson, P; Jensen, TS; Kemp, H; Kennedy, D; Leffler, A-S; Rice, ASC; Segerdahl, M; Serra, J; Sindrup, S; Solà, R; Tölle, T; Schuh-Hofer, S; Treede, R-D; Pogatzki-Zahn, E; Maier, C; Vollert, J
Contributor organization: Department of Diagnostics and Therapeutics
Helsinki University Hospital Area
Date: 2020-07
Language: eng
Number of pages: 14
Belongs to series: European Journal of Pain
ISSN: 1090-3801
Abstract: Abstract Background and aims Healthy women have generally been found to have increased experimental pain perception and chronic pain has a higher prevalence in female as compared to male patients. However, no study has investigated whether pain intensity and pain perception thresholds are distinct or similar between sexes within various chronic pain entities. We investigated whether average pain intensities and pain thresholds assessed using quantitative sensory testing (QST) differed between women and men suffering from three distinct chronic pain conditions: Complex Regional Pain Syndrome (CRPS type I), peripheral nerve injury (PNI) or polyneuropathy (PNP), as compared to paired healthy volunteers. Methods QST data of 1252 patients (669 female, 583 male) with PNI (n=342), PNP (n=571) or CRPS (n=339), and average pain intensity reports from previously published studies were included. Absolute and z-values (adjusted for age and body region) of cold, heat, pressure (PPT) and pinprick pain thresholds were compared in generalized linear models with aetiology, duration of underlying pain disease and average pain intensity as fixed effects. Results Average pain intensity during the past four weeks did not differ between women and men, in both mean and range. In women absolute pain thresholds for cold, heat and pinprick were lower than in males across all diagnoses (p
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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