Preimplantation genetic testing legislation and accessibility in the Nordic countries

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http://hdl.handle.net/10138/327100

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Hreinsson , J , Lundin , K , Iwarsson , E , Hausken , J , Einarsson , S , Grøndahl , M L , Hydén-Granskog , C & Ingerslev , H J 2020 , ' Preimplantation genetic testing legislation and accessibility in the Nordic countries ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 99 , no. 6 , pp. 716-721 . https://doi.org/10.1111/aogs.13831

Title: Preimplantation genetic testing legislation and accessibility in the Nordic countries
Author: Hreinsson, Julius; Lundin, Kersti; Iwarsson, Erik; Hausken, Jon; Einarsson, Snorri; Grøndahl, Marie Louise; Hydén-Granskog, Christel; Ingerslev, Hans Jakob
Contributor: University of Helsinki, HUS Helsinki and Uusimaa Hospital District
Date: 2020-06
Language: eng
Number of pages: 6
Belongs to series: Acta Obstetricia et Gynecologica Scandinavica
ISSN: 0001-6349
URI: http://hdl.handle.net/10138/327100
Abstract: Abstract Introduction Assisted Reproduction Technologies are in rapid development and implementation of preimplantation genetic testing (PGT) has allowed patients with genetic disorders to initiate pregnancies while minimizing or eliminating the risk of transmitting these disorders to their offspring. Testing for numeric chromosomal anomalies has been proposed as a way to increase efficacy in assisted reproduction, however this remains disputed. Legislation is lagging behind the rapid developments in this field. Material and methods We conducted a structured online survey of legislation and accessibility to Preimplantation Genetic Testing in the Nordic countries to compare the regulation and uptake of this technique. The survey was designed and answered by the authors. Results Key elements in regulation of preimplantation testing for monogenic disorders and structural rearrangements are similar in the Nordic countries although accessibility varies since only Denmark, Finland and Sweden have national clinics offering treatment. In addition, Denmark and Finland have private clinics offering PGT. Regulation is most stringent in Norway where a national board evaluates all couples seeking treatment. Treatment volumes vary between the Nordic countries with Norway and Finland having lowest treatment numbers. Preimplantation genetic testing for aneuploidy in the embryo varies between the Nordic countries where Finland and Iceland are allowed to offer this form of treatment, Denmark and Sweden only in the form of a research protocol while this form of testing is not allowed at all in Norway. Therefore the number of treatment cycles involving testing for embryo aneuploidy are lower in the Nordic countries compared to other countries where this treatment option is more common. Conclusions Science needs to inform politics regarding the rapidly evolving field of reproductive medicine and we recommend harmonization of legislation and accessibility between the Nordic countries.
Subject: aneuploidies
assisted reproductive technologies
Legislation in ART
monogenic disorders
Nordic
PGT legislation
preimplantation genetic testing
structural rearrangements
DIAGNOSIS
preimplantation genetic testing legislation
legislation in assisted reproductive technologies
ANEUPLOIDY
DNA
AGE
3123 Gynaecology and paediatrics
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