Interaction Between Alcohol Use and Metabolic Risk Factors for Liver Disease : A Critical Review of Epidemiological Studies

Show simple item record Åberg, Fredrik Färkkilä, Martti Männistö, Ville 2021-02-26T08:55:02Z 2021-12-18T03:45:56Z 2020-02
dc.identifier.citation Åberg , F , Färkkilä , M & Männistö , V 2020 , ' Interaction Between Alcohol Use and Metabolic Risk Factors for Liver Disease : A Critical Review of Epidemiological Studies ' , Alcoholism: Clinical and Experimental Research , vol. 44 , no. 2 , pp. 384-403 .
dc.identifier.other PURE: 131012101
dc.identifier.other PURE UUID: 7d472201-1220-49b4-ab80-5a1d67b08d00
dc.identifier.other WOS: 000506323900001
dc.identifier.other ORCID: /0000-0002-0250-8559/work/76331833
dc.description.abstract Coexistence of alcohol use and metabolic risk-the 2 commonest population risk factors for nonviral chronic liver disease-is a growing concern. Clinical evidence and mechanistic evidence point to considerable supraadditive interaction effects for the development and progression of chronic liver disease between hazardous alcohol use and metabolic abnormalities including obesity, diabetes, and the metabolic syndrome (MetS). Intermittent binge drinking once monthly or more often seems to be associated with progression of liver disease even when average alcohol intake is within the currently allowed limits for a diagnosis of nonalcoholic fatty liver disease (NAFLD), and supraadditive interaction between binge drinking and the MetS has been reported. There are contradictory findings regarding the association between low alcohol use and liver steatosis, but, clearly, the mechanisms of alcoholic hepatotoxicity extend beyond simple fat accumulation. The presence of liver steatosis seems to amplify alcoholic hepatotoxicity. Recent longitudinal studies of NAFLD subjects report low alcohol use associated with both increased fibrosis progression and an elevated risk for liver cancer and severe liver disease. There is no clear safe limit of alcohol intake in the presence of NAFLD or metabolic risk. The interaction effects between alcohol and metabolic dysfunction merit increased attention in public health policy, individual counseling, and risk stratification. Based on current evidence, a strict dichotomization of liver disease into either pure alcoholic or nonalcoholic may be inappropriate. en
dc.format.extent 20
dc.language.iso eng
dc.relation.ispartof Alcoholism: Clinical and Experimental Research
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Liver Cirrhosis
dc.subject Drinking
dc.subject Metabolic Syndrome
dc.subject NAFLD
dc.subject Alcoholic
dc.subject BODY-MASS INDEX
dc.subject FATTY LIVER
dc.subject CONSUMPTION
dc.subject PREVALENCE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Interaction Between Alcohol Use and Metabolic Risk Factors for Liver Disease : A Critical Review of Epidemiological Studies en
dc.type Review Article
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization IV kirurgian klinikka
dc.contributor.organization University of Helsinki
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Department of Medicine
dc.contributor.organization Gastroenterologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0145-6008
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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