Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity

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Koivusaari , K , Syrjälä , E , Niinistö , S , Takkinen , H-M , Ahonen , S , Åkerlund , M , Korhonen , T E , Toppari , J , Ilonen , J , Peltonen , J , Nevalainen , J , Knip , M , Alatossava , T , Veijola , R & Virtanen , S M 2020 , ' Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity ' , British Journal of Nutrition , vol. 124 , no. 2 , 0007114520000744 , pp. 173-180 . https://doi.org/10.1017/S0007114520000744

Title: Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity
Author: Koivusaari, Katariina; Syrjälä, Essi; Niinistö, Sari; Takkinen, Hanna-Mari; Ahonen, Suvi; Åkerlund, Mari; Korhonen, Tuuli E.; Toppari, Jorma; Ilonen, Jorma; Peltonen, Jaakko; Nevalainen, Jaakko; Knip, Mikael; Alatossava, Tapani; Veijola, Riitta; Virtanen, Suvi M
Other contributor: University of Helsinki, Department of Food and Nutrition
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Helsinki Institute of Sustainability Science (HELSUS)







Date: 2020-07-28
Language: eng
Number of pages: 8
Belongs to series: British Journal of Nutrition
ISSN: 0007-1145
DOI: https://doi.org/10.1017/S0007114520000744
URI: http://hdl.handle.net/10138/327189
Abstract: Several prospective studies have shown an association between cows’ milk consumption and the risk of islet autoimmunity and/or type 1 diabetes. We wanted to study whether processing of milk plays a role. A population-based birth cohort of 6081 children with HLA-DQB1-conferred risk to type 1 diabetes was followed until the age of 15 years. We included 5545 children in the analyses. Food records were completed at the ages of 3 and 6 months and 1, 2, 3, 4 and 6 years, and diabetes-associated autoantibodies were measured at 3–12-month intervals. For milk products in the food composition database, we used conventional and processing-based classifications. We analysed the data using a joint model for longitudinal and time-to-event data. By the age of 6 years, islet autoimmunity developed in 246 children. Consumption of all cows’ milk products together (energy-adjusted hazard ratio 1·06; 95 % CI 1·02, 1·11; P = 0·003), non-fermented milk products (1·06; 95 % CI 1·01, 1·10; P = 0·011) and fermented milk products (1·35; 95 % CI 1·10, 1·67; P = 0·005) was associated with an increased risk of islet autoimmunity. The early milk consumption was not associated with the risk beyond 6 years. We observed no clear differences based on milk homogenisation and heat treatment. Our results are consistent with the previous studies, which indicate that high milk consumption may cause islet autoimmunity in children at increased genetic risk. The study did not identify any specific type of milk processing that would clearly stand out as a sole risk factor apart from other milk products.
Subject: 3143 Nutrition
Children
Milk products
Islet autoimmunity
Homogenisation
Children
Milk products
Islet autoimmunity
Homogenisation
Heat treatment
Joint models
Survival analysis
TYPE-1 DIABETES-MELLITUS
YOUNG-CHILDREN
HOMOGENIZATION
AUTOANTIBODIES
PASTEURIZATION
IMMUNOGENICITY
GENOTYPE
SIBLINGS
FORMULA
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