Comparative Genomics Platform and Phylogenetic Analysis of Fungal Laccases and Multi-Copper Oxidases

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http://hdl.handle.net/10138/327198

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Wu , J , Choi , J , Asiegbu , F O & Lee , Y-H 2020 , ' Comparative Genomics Platform and Phylogenetic Analysis of Fungal Laccases and Multi-Copper Oxidases ' , Mycobiology , vol. 48 , no. 5 , pp. 373-382 . https://doi.org/10.1080/12298093.2020.1816151

Title: Comparative Genomics Platform and Phylogenetic Analysis of Fungal Laccases and Multi-Copper Oxidases
Author: Wu, Jiayao; Choi, Jaeyoung; Asiegbu, Fred O.; Lee, Yong-Hwan
Contributor organization: Department of Forest Sciences
Helsinki Institute of Sustainability Science (HELSUS)
Viikki Plant Science Centre (ViPS)
Forest Ecology and Management
Date: 2020-09
Language: eng
Number of pages: 10
Belongs to series: Mycobiology
ISSN: 1229-8093
DOI: https://doi.org/10.1080/12298093.2020.1816151
URI: http://hdl.handle.net/10138/327198
Abstract: Abstract Laccases (EC 1.10.3.2), a group of multi-copper oxidases (MCOs), play multiple biological functions and widely exist in many species. Fungal laccases have been extensively studied for their industrial applications, however, there was no database specially focused on fungal laccases. To provide a comparative genomics platform for fungal laccases, we have developed a comparative genomics platform for laccases and MCOs (http://laccase.riceblast.snu.ac.kr/). Based on protein domain profiles of characterized sequences, 3,571 laccases were predicted from 690 genomes including 253 fungi. The number of putative laccases and their properties exhibited dynamic distribution across the taxonomy. A total of 505 laccases from 68 genomes were selected and subjected to phylogenetic analysis. As a result, four clades comprised of nine subclades were phylogenetically grouped by their putative functions and analyzed at the sequence level. Our work would provide a workbench for putative laccases mainly focused on the fungal kingdom as well as a new perspective in the identification and classification of putative laccases and MCOs.
Subject: 11831 Plant biology
11832 Microbiology and virology
Laccase
multicopper oxidase
database
phylogenetic analysis
fungal genome
MULTICOPPER OXIDASE
LIGNIN DEGRADATION
MOLECULAR CHARACTERIZATION
TRANSCRIPTIONAL REGULATION
BILIRUBIN OXIDASE
BACILLUS-SUBTILIS
ASCORBATE OXIDASE
LENTINULA-EDODES
GENE
BLUE
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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