Contrasting microbiotas between Finnish and Estonian infants : exposure to Acinetobacter may contribute to the allergy gap

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http://hdl.handle.net/10138/327210

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Ruokolainen , L , Parkkola , A , Karkman , A , Sinkko , H , Peet , A , Hämäläinen , A-M , von Hertzen , L , Tillmann , V , Koski , K , Virtanen , S M , Niemelä , O , Haahtela , T & Knip , M 2020 , ' Contrasting microbiotas between Finnish and Estonian infants : exposure to Acinetobacter may contribute to the allergy gap ' , Allergy : European journal of allergy and clinical immunology , vol. 75 , no. 9 , pp. 2342-2351 . https://doi.org/10.1111/all.14250

Title: Contrasting microbiotas between Finnish and Estonian infants : exposure to Acinetobacter may contribute to the allergy gap
Author: Ruokolainen, Lasse; Parkkola, Anna; Karkman, Antti; Sinkko, Hanna; Peet, Aleksandr; Hämäläinen, Anu-Maaria; von Hertzen, Leena; Tillmann, Vallo; Koski, Katriina; Virtanen, Suvi M.; Niemelä, Onni; Haahtela, Tari; Knip, Mikael
Contributor organization: Helsinki Institute of Sustainability Science (HELSUS)
Biosciences
Veijo Kaitala / Principal Investigator
University of Helsinki
HUS Children and Adolescents
Children's Hospital
Research Programs Unit
Faculty of Medicine
CAMM - Research Program for Clinical and Molecular Metabolism
Department of Microbiology
HUMI - Human Microbiome Research
Helsinki University Hospital Area
Department of Dermatology, Allergology and Venereology
HUS Inflammation Center
Date: 2020-09
Language: eng
Number of pages: 10
Belongs to series: Allergy : European journal of allergy and clinical immunology
ISSN: 0105-4538
DOI: https://doi.org/10.1111/all.14250
URI: http://hdl.handle.net/10138/327210
Abstract: Background Allergic diseases are more common in Finland than in Estonia, which-according to the biodiversity hypothesis-could relate to differences in early microbial exposures. Methods We aimed at defining possible microbial perturbations preceding early atopic sensitization. Stool, nasal and skin samples of 6-month-old DIABIMMUNE study participants with HLA susceptibility to type 1 diabetes were collected. We compared microbiotas of sensitized (determined by specific IgE results at 18 months of age) and unsensitized Estonian and Finnish children. Results Sensitization was differentially targeted between populations, as egg-specific and birch pollen-specific IgE was more common in Finland. Microbial diversity and community composition also differed; the genusAcinetobacterwas more abundant in Estonian skin and nasal samples. Particularly, the strain-level profile ofAcinetobacter lwoffiiwas more diverse in Estonian samples. Early microbiota was not generally associated with later sensitization. Microbial composition tended to differ between children with or without IgE-related sensitization, but only in Finland. While land-use pattern (ie green areas vs. urban landscapes around the children's homes) was not associated with microbiota as a whole, it associated with the composition of the genusAcinetobacter. Breastfeeding affected gut microbial composition and seemed to protect from sensitization. Conclusions In accordance with the biodiversity hypothesis, our results support disparate early exposure to environmental microbes between Finnish and Estonian children and suggest a significant role of the genusAcinetobacterin the allergy gap between the two populations. The significance of the observed differences for later allergic sensitization remains open.
Subject: 3111 Biomedicine
atopic sensitisation
IgE
intestine
microbiota
respiratory
skin
EARLY-LIFE
atopic sensitization
RISK
PREVALENCE
ENVIRONMENTAL BIODIVERSITY
DISPARITIES
DISEASE
ASTHMA
DIVERSITY
SKIN
ATOPIC SENSITIZATION
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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