Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis

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Fontana , F , Albertini , S , Correia , A , Kemell , M L , Lindgren , R , Mäkilä , E , Salonen , J , Hirvonen , J T , Ferrari , F & Almeida Santos , H 2018 , ' Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis ' , Advanced Functional Materials , vol. 28 , no. 22 , 1801355 . https://doi.org/10.1002/adfm.201801355

Title: Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis
Author: Fontana, Flavia; Albertini, Silvia; Correia, Alexandra; Kemell, Marianna Leena; Lindgren, Rici; Mäkilä, Ermei; Salonen, Jarno; Hirvonen, Jouni Tapio; Ferrari, Franca; Almeida Santos, Helder
Other contributor: University of Helsinki, Preclinical Drug Formulation and Analysis group
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Department of Chemistry
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program






Date: 2018-05-30
Language: eng
Number of pages: 10
Belongs to series: Advanced Functional Materials
ISSN: 1616-3028
DOI: https://doi.org/10.1002/adfm.201801355
URI: http://hdl.handle.net/10138/327318
Abstract: Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as antigenic sources of vaccines. The optimization and functionality parameters of these nanosystems vary depending on the properties of the core particles. In this work, the effects of the core particles’ surface charge and hydrophobicity are evaluated on the nanosystem coating with vesicles derived from plasma membrane. The measured parameters are the dimensions, surface charge, shape, and stability of the biohybrid nanosystems, both in buffer and in biologically relevant media (plasma and simulated synovial fluid). Moreover, the cytocompatibility properties of the developed nanosystems are evaluated in different cell lines mimicking the target cell populations and other districts of the body involved in the distribution and elimination of the nanoparticles. Finally, the immunological profile of the particles is investigated, highlighting the absence of immune activation promoted by the nanoplatforms.
Subject: 116 Chemical sciences
317 Pharmacy
autoimmune diseases
cell membrane
macrophages
nanoparticles
porous silicon
POLYMERIC NANOPARTICLES
ERYTHROCYTE-MEMBRANE
DRUG-DELIVERY
PARTICLE-SIZE
THERAPY
BIODISTRIBUTION
AUTOIMMUNITY
CIRCULATION
INSIGHTS
ANTIGEN
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