Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence

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Xia , G , Zhang , H , Cheng , R , Wang , H , Song , Z , Deng , L , Huang , X , Santos , H A & Cui , W 2018 , ' Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence ' , Advanced Healthcare Materials , vol. 7 , no. 18 , 1800593 . https://doi.org/10.1002/adhm.201800593

Title: Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence
Author: Xia, Guanggai; Zhang, Hongbo; Cheng, Ruoyu; Wang, Hongcheng; Song, Ziliang; Deng, Lianfu; Huang, Xinyu; Santos, Helder A.; Cui, Wenguo
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Chemistry and Technology
Preclinical Drug Formulation and Analysis group
Drug Research Program
Nanomedicines and Biomedical Engineering
Date: 2018-09-19
Language: eng
Number of pages: 13
Belongs to series: Advanced Healthcare Materials
ISSN: 2192-2640
DOI: https://doi.org/10.1002/adhm.201800593
URI: http://hdl.handle.net/10138/327331
Abstract: The low radical surgery rate of pancreatic cancer leads to increased local recurrence and poor prognosis. Gemcitabine (GEM) is the preferred chemotherapeutic for pancreatic cancer. However, systemic chemotherapy with GEM has reached a bottleneck due to its serious side effects after frequent injections. In this study, GEM is successfully enwrapped into electrospun fibers via microsol electrospinning technology to form a stable core-shell fibrous structure. The GEM release rate can be adjusted by altering the thickness of the hyaluronan-sol inner fiber and the quantity of loaded GEM, and the release can be sustained for as long as three weeks. In vitro assays show that these electrospun fibers effectively inhibit pancreatic cancer cells and promote apoptosis. In vivo studies show that the fibrous membranes are better for inhibiting the growth of residual tumors than that of integrated tumors. Furthermore, immunohistochemistry results show that GEM-loaded fibers promote a higher cell apoptosis rate than does systemically injected GEM in residual tumors. In addition, the local delivery of GEM with fibers significantly reduces liver toxicity. In summary, a core-shell electrospun fiber for the controlled and localized delivery of GEM, which greatly improves the treatment of residual tumors and prevents pancreatic tumor recurrence, is developed.
Subject: core-shell
electrospun fibers
gemcitabine
pancreatic cancer
residual tumors
TUMOR-STROMA INTERACTIONS
DUCTAL ADENOCARCINOMA
DRUG-DELIVERY
ADJUVANT CHEMOTHERAPY
RANDOMIZED-TRIAL
RELEASE
NANOFIBERS
SURVIVAL
THERAPY
FIBROBLASTS
317 Pharmacy
216 Materials engineering
221 Nano-technology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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