Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity

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Liu , D , Chen , J , Jiang , T , Li , W , Huang , Y , Lu , X , Liu , Z , Zhang , W , Zhou , Z , Ding , Q , Almeida Santos , H , Yin , G & Fan , J 2018 , ' Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity ' , Advanced Materials , vol. 30 , no. 14 , 1706032 . https://doi.org/10.1002/adma.201706032

Title: Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity
Author: Liu, Dongfei; Chen, Jian; Jiang, Tao; Li, Wei; Huang, Yao; Lu, Xiyi; Liu, Zehua; Zhang, Weixia; Zhou, Zheng; Ding, Qirui; Almeida Santos, Helder; Yin, Guoyong; Fan, Jin
Other contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy




Date: 2018-04-05
Language: eng
Number of pages: 11
Belongs to series: Advanced Materials
ISSN: 0935-9648
DOI: https://doi.org/10.1002/adma.201706032
URI: http://hdl.handle.net/10138/327344
Abstract: New treatment strategies for spinal cord injury with good therapeutic efficacy are actively pursued. Here, acetalated dextran (AcDX), a biodegradable polymer obtained by modifying vicinal diols of dextran, is demonstrated to protect the traumatically injured spinal cord. To facilitate its administration, AcDX is formulated into microspheres (approximate to 7.2 mu m in diameter) by the droplet microfluidic technique. Intrathecally injected AcDX microspheres effectively reduce the traumatic lesion volume and inflammatory response in the injured spinal cord, protect the spinal cord neurons from apoptosis, and ultimately, recover the locomotor function of injured rats. The neuroprotective feature of AcDX microspheres is achieved by sequestering glutamate and calcium ions in cerebrospinal fluid. The scavenging of glutamate and calcium ion reduces the influx of calcium ions into neurons and inhibits the formation of reactive oxygen species. Consequently, AcDX microspheres attenuate the expression of proapoptotic proteins, Calpain, and Bax, and enhance the expression of antiapoptotic protein Bcl-2. Overall, AcDX microspheres protect traumatically injured spinal cord by alleviating the glutamate-induced excitotoxicity. This study opens an exciting perspective toward the application of neuroprotective AcDX for the treatment of severe neurological diseases.
Subject: 116 Chemical sciences
221 Nano-technology
114 Physical sciences
317 Pharmacy
acetalated dextran
alleviated excitotoxicity
calcium ion scavenging
glutamate adsorption
spinal cord injury
ACETALATED DEXTRAN MICROPARTICLES
CEREBROSPINAL-FLUID GLUTAMATE
DRUG-DELIVERY
NEURODEGENERATIVE DISEASES
MULTIDRUG DELIVERY
APOPTOSIS
REGENERATION
PATHOGENESIS
RELEASE
POLYMER
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