Nuts and Bolts : Microfluidics for the Production of Biomaterials

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http://hdl.handle.net/10138/327356

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Fontana , F , Martins , J P , Torrieri , G & Santos , H A 2019 , ' Nuts and Bolts : Microfluidics for the Production of Biomaterials ' , Advanced Materials Technologies , vol. 4 , no. 6, SI , 1800611 . https://doi.org/10.1002/admt.201800611

Titel: Nuts and Bolts : Microfluidics for the Production of Biomaterials
Författare: Fontana, Flavia; Martins, Joao P.; Torrieri, Giulia; Santos, Helder A.
Upphovmannens organisation: Nanomedicines and Biomedical Engineering
Division of Pharmaceutical Chemistry and Technology
Drug Research Program
Preclinical Drug Formulation and Analysis group
University Management
Helsinki Institute of Life Science HiLIFE
Datum: 2019-06
Språk: eng
Sidantal: 21
Tillhör serie: Advanced Materials Technologies
ISSN: 2365-709X
DOI: https://doi.org/10.1002/admt.201800611
Permanenta länken (URI): http://hdl.handle.net/10138/327356
Abstrakt: Nanotechnology holds the promise of bringing revolutionary therapeutic strategies into the clinic. However, an enormous fraction of the currently proposed nanotechnology-based therapies suffers from lack of reproducibility, complexity, high costs, and scale-up-related issues. For these reasons, the research community is moving toward the miniaturization of biomaterials and fabrication methods. Customizable microfluidic-based products have gained tremendous relevance in the development of biomedical technologies. This review provides an overview of different materials that can be used for the fabrication of microfluidic devices, as well as the other parameters influencing the production of biomaterials and biosensors. Moreover, several advanced microfluidic-based technologies that are designed to overcome the current challenges of cancer, immunotherapy, and diabetes therapy, among others are described. Then, the pros and cons of microfluidics as alternative to conventional preparation methods, and the challenges of translating this technique to an industrial context are highlighted. Overall, microfluidic technologies and their accessibility to the research community offer a set of exciting opportunities to bridge the development of innovative therapies and their commercialization in the foreseeable future.
Subject: biomaterials
biosensors
drug delivery systems
microfluidics
MONODISPERSE DOUBLE EMULSIONS
DRUG-DELIVERY
ORAL DELIVERY
POLYMERIC NANOPARTICLES
DROPLET FORMATION
DPP4 INHIBITOR
CHIP
INSULIN
SYSTEMS
NANOTECHNOLOGY
317 Pharmacy
221 Nano-technology
216 Materials engineering
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion


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