Nuts and Bolts : Microfluidics for the Production of Biomaterials

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dc.contributor.author Fontana, Flavia
dc.contributor.author Martins, Joao P.
dc.contributor.author Torrieri, Giulia
dc.contributor.author Santos, Helder A.
dc.date.accessioned 2021-03-02T14:29:02Z
dc.date.available 2021-03-02T14:29:02Z
dc.date.issued 2019-06
dc.identifier.citation Fontana , F , Martins , J P , Torrieri , G & Santos , H A 2019 , ' Nuts and Bolts : Microfluidics for the Production of Biomaterials ' , Advanced Materials Technologies , vol. 4 , no. 6, SI , 1800611 . https://doi.org/10.1002/admt.201800611
dc.identifier.other PURE: 126024423
dc.identifier.other PURE UUID: c3ca3c02-1929-4a17-aeef-0e282052f14c
dc.identifier.other WOS: 000474175500010
dc.identifier.other Scopus: 85059514689
dc.identifier.other ORCID: /0000-0001-9112-6917/work/60407266
dc.identifier.other ORCID: /0000-0001-8300-4661/work/60407553
dc.identifier.other ORCID: /0000-0001-7577-9280/work/60407963
dc.identifier.other ORCID: /0000-0001-7850-6309/work/103469219
dc.identifier.uri http://hdl.handle.net/10138/327356
dc.description.abstract Nanotechnology holds the promise of bringing revolutionary therapeutic strategies into the clinic. However, an enormous fraction of the currently proposed nanotechnology-based therapies suffers from lack of reproducibility, complexity, high costs, and scale-up-related issues. For these reasons, the research community is moving toward the miniaturization of biomaterials and fabrication methods. Customizable microfluidic-based products have gained tremendous relevance in the development of biomedical technologies. This review provides an overview of different materials that can be used for the fabrication of microfluidic devices, as well as the other parameters influencing the production of biomaterials and biosensors. Moreover, several advanced microfluidic-based technologies that are designed to overcome the current challenges of cancer, immunotherapy, and diabetes therapy, among others are described. Then, the pros and cons of microfluidics as alternative to conventional preparation methods, and the challenges of translating this technique to an industrial context are highlighted. Overall, microfluidic technologies and their accessibility to the research community offer a set of exciting opportunities to bridge the development of innovative therapies and their commercialization in the foreseeable future. en
dc.format.extent 21
dc.language.iso eng
dc.relation.ispartof Advanced Materials Technologies
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject biomaterials
dc.subject biosensors
dc.subject drug delivery systems
dc.subject microfluidics
dc.subject MONODISPERSE DOUBLE EMULSIONS
dc.subject DRUG-DELIVERY
dc.subject ORAL DELIVERY
dc.subject POLYMERIC NANOPARTICLES
dc.subject DROPLET FORMATION
dc.subject DPP4 INHIBITOR
dc.subject CHIP
dc.subject INSULIN
dc.subject SYSTEMS
dc.subject NANOTECHNOLOGY
dc.subject 317 Pharmacy
dc.subject 221 Nano-technology
dc.subject 216 Materials engineering
dc.title Nuts and Bolts : Microfluidics for the Production of Biomaterials en
dc.type Review Article
dc.contributor.organization Nanomedicines and Biomedical Engineering
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.contributor.organization Drug Research Program
dc.contributor.organization Preclinical Drug Formulation and Analysis group
dc.contributor.organization University Management
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1002/admt.201800611
dc.relation.issn 2365-709X
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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