Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates

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Zhang , H , Zhu , Y , Qu , L , Wu , H , Kong , H , Yang , Z , Chen , D , Mäkilä , E , Salonen , J , Santos , H A , Hai , M & Weitz , D A 2018 , ' Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates ' , Nano Letters , vol. 18 , no. 2 , pp. 1448-1453 . https://doi.org/10.1021/acs.nanolett.7b05210

Title: Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates
Author: Zhang, Hongbo; Zhu, Yueqi; Qu, Liangliang; Wu, Huayin; Kong, Haixin; Yang, Zhou; Chen, Dong; Mäkilä, Ermei; Salonen, Jarno; Santos, Helder A.; Hai, Mingtan; Weitz, David A.
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Chemistry and Technology
Preclinical Drug Formulation and Analysis group
Drug Research Program
Nanomedicines and Biomedical Engineering
Date: 2018-02
Language: eng
Number of pages: 6
Belongs to series: Nano Letters
ISSN: 1530-6984
DOI: https://doi.org/10.1021/acs.nanolett.7b05210
URI: http://hdl.handle.net/10138/327362
Abstract: Porous silicon nanoparticles (PSiNPs) and gold nanorods (AuNRs) can be used as biocompatible nanocarriers for delivery of therapeutics but undesired leakage makes them inefficient. By encapsulating the PSiNPs and AuNRs in a hydrogel shell, we create a biocompatible functional nano carrier that enables sustained release of therapeutics. Here, we report the fabrication of AuNRs-conjugated PSi nanoparticles (AuNRsPSiNPs) through two-step chemical reaction for high capacity loading of hydrophobic and hydrophilic therapeutics with photothermal property. Furthermore, using water-in-oil microemulsion templates, we encapsulate the AuNRsPSiNPs within a calcium alginate hydrogel nanoshell, creating a versatile biocompatible nanocarrier to codeliver therapeutics for biomedical applications. We find that the functionalized nanohydrogel effectively controls the release rate of the therapeutics while maintaining a high loading efficiency and tunable loading ratios. Notably, combinations of therapeutics coloaded in the functionalized nanohydrogels significantly enhance inhibition of multidrug resistance through synergism and promote faster cancer cell death when combined with photothermal therapy. Moreover, the AuNRs can mediate the conversion of near-infrared laser radiation into heat, increasing the release of therapeutics as well as thermally inducing cell damage to promote faster cancer cell death. Our AuNRsPSiNPs functionalized calcium alginate nanohydrogel holds great promise for photothermal combination therapy and other advanced biomedical applications.
Subject: Calcium alginate nano hydrogel
gold nanorods conjugated porous silicon nanoparticles
photothermal therapy
multidrug resistance inhibition
biomedical applications
DELIVERY
THERAPY
INHIBITION
PLATFORM
PROTEIN
116 Chemical sciences
221 Nano-technology
216 Materials engineering
317 Pharmacy
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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