A serological assay to detect SARS-CoV-2 seroconversion in humans

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http://hdl.handle.net/10138/327413

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Amanat , F , Stadlbauer , D , Strohmeier , S , Nguyen , T H O , Chromikova , V , McMahon , M , Jiang , K , Arunkumar , G A , Jurczyszak , D , Polanco , J , Bermudez-Gonzalez , M , Kleiner , G , Aydillo , T , Miorin , L , Fierer , D S , Lugo , L A , Kojic , E M , Stoever , J , Liu , S T H , Cunningham-Rundles , C , Felgner , P L , Moran , T , Garcia-Sastre , A , Caplivski , D , Cheng , A C , Kedzierska , K , Vapalahti , O , Hepojoki , J M , Simon , V & Krammer , F 2020 , ' A serological assay to detect SARS-CoV-2 seroconversion in humans ' , Nature Medicine , vol. 26 , no. 7 , pp. 1033-+ . https://doi.org/10.1038/s41591-020-0913-5

Title: A serological assay to detect SARS-CoV-2 seroconversion in humans
Author: Amanat, Fatima; Stadlbauer, Daniel; Strohmeier, Shirin; Nguyen, Thi H. O.; Chromikova, Veronika; McMahon, Meagan; Jiang, Kaijun; Arunkumar, Guha Asthagiri; Jurczyszak, Denise; Polanco, Jose; Bermudez-Gonzalez, Maria; Kleiner, Giulio; Aydillo, Teresa; Miorin, Lisa; Fierer, Daniel S.; Lugo, Luz Amarilis; Kojic, Erna Milunka; Stoever, Jonathan; Liu, Sean T. H.; Cunningham-Rundles, Charlotte; Felgner, Philip L.; Moran, Thomas; Garcia-Sastre, Adolfo; Caplivski, Daniel; Cheng, Allen C.; Kedzierska, Katherine; Vapalahti, Olli; Hepojoki, Jussi M.; Simon, Viviana; Krammer, Florian
Contributor: University of Helsinki, Department of Virology
University of Helsinki, Helsinki One Health (HOH)
Date: 2020-07
Language: eng
Number of pages: 12
Belongs to series: Nature Medicine
ISSN: 1078-8956
URI: http://hdl.handle.net/10138/327413
Abstract: Development of an enzyme-linked immunosorbent assay to detect antibodies to the SARS-CoV-2 spike protein in human sera and plasma. Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection.
Subject: SARS CORONAVIRUS
SPIKE
ANTIBODIES
BINDING
3111 Biomedicine
11832 Microbiology and virology
1182 Biochemistry, cell and molecular biology
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