A serological assay to detect SARS-CoV-2 seroconversion in humans

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dc.contributor.author Amanat, Fatima
dc.contributor.author Stadlbauer, Daniel
dc.contributor.author Strohmeier, Shirin
dc.contributor.author Nguyen, Thi H. O.
dc.contributor.author Chromikova, Veronika
dc.contributor.author McMahon, Meagan
dc.contributor.author Jiang, Kaijun
dc.contributor.author Arunkumar, Guha Asthagiri
dc.contributor.author Jurczyszak, Denise
dc.contributor.author Polanco, Jose
dc.contributor.author Bermudez-Gonzalez, Maria
dc.contributor.author Kleiner, Giulio
dc.contributor.author Aydillo, Teresa
dc.contributor.author Miorin, Lisa
dc.contributor.author Fierer, Daniel S.
dc.contributor.author Lugo, Luz Amarilis
dc.contributor.author Kojic, Erna Milunka
dc.contributor.author Stoever, Jonathan
dc.contributor.author Liu, Sean T. H.
dc.contributor.author Cunningham-Rundles, Charlotte
dc.contributor.author Felgner, Philip L.
dc.contributor.author Moran, Thomas
dc.contributor.author Garcia-Sastre, Adolfo
dc.contributor.author Caplivski, Daniel
dc.contributor.author Cheng, Allen C.
dc.contributor.author Kedzierska, Katherine
dc.contributor.author Vapalahti, Olli
dc.contributor.author Hepojoki, Jussi M.
dc.contributor.author Simon, Viviana
dc.contributor.author Krammer, Florian
dc.date.accessioned 2021-03-03T10:54:01Z
dc.date.available 2021-03-03T10:54:01Z
dc.date.issued 2020-07
dc.identifier.citation Amanat , F , Stadlbauer , D , Strohmeier , S , Nguyen , T H O , Chromikova , V , McMahon , M , Jiang , K , Arunkumar , G A , Jurczyszak , D , Polanco , J , Bermudez-Gonzalez , M , Kleiner , G , Aydillo , T , Miorin , L , Fierer , D S , Lugo , L A , Kojic , E M , Stoever , J , Liu , S T H , Cunningham-Rundles , C , Felgner , P L , Moran , T , Garcia-Sastre , A , Caplivski , D , Cheng , A C , Kedzierska , K , Vapalahti , O , Hepojoki , J M , Simon , V & Krammer , F 2020 , ' A serological assay to detect SARS-CoV-2 seroconversion in humans ' , Nature Medicine , vol. 26 , no. 7 , pp. 1033-+ . https://doi.org/10.1038/s41591-020-0913-5
dc.identifier.other PURE: 138518925
dc.identifier.other PURE UUID: 35977533-7470-44e7-a31b-37781957de41
dc.identifier.other WOS: 000532113900001
dc.identifier.other ORCID: /0000-0001-5699-214X/work/79876785
dc.identifier.other ORCID: /0000-0003-2270-6824/work/79877703
dc.identifier.uri http://hdl.handle.net/10138/327413
dc.description.abstract Development of an enzyme-linked immunosorbent assay to detect antibodies to the SARS-CoV-2 spike protein in human sera and plasma. Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Nature Medicine
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject SARS CORONAVIRUS
dc.subject SPIKE
dc.subject ANTIBODIES
dc.subject BINDING
dc.subject 3111 Biomedicine
dc.subject 11832 Microbiology and virology
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title A serological assay to detect SARS-CoV-2 seroconversion in humans en
dc.type Article
dc.contributor.organization Department of Virology
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Olli Pekka Vapalahti / Principal Investigator
dc.contributor.organization Viral Zoonosis Research Unit
dc.contributor.organization Veterinary Microbiology and Epidemiology
dc.contributor.organization HUSLAB
dc.contributor.organization Medicum
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41591-020-0913-5
dc.relation.issn 1078-8956
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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