Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test

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De Marinis , Y , Sunnerhagen , T , Bompada , P , Bläckberg , A , Yang , R , Svensson , J , Ekström , O , Eriksson , K-F , Hansson , O , Groop , L , Gonçalves , I & Rasmussen , M 2020 , ' Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test ' , Infection ecology & epidemiology , vol. 10 , no. 1 , 1821513 . https://doi.org/10.1080/20008686.2020.1821513

Title: Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test
Author: De Marinis, Yang; Sunnerhagen, Torgny; Bompada, Pradeep; Bläckberg, Anna; Yang, Runtao; Svensson, Joel; Ekström, Ola; Eriksson, Karl-Fredrik; Hansson, Ola; Groop, Leif; Gonçalves, Isabel; Rasmussen, Magnus
Contributor organization: Institute for Molecular Medicine Finland
Centre of Excellence in Complex Disease Genetics
HUS Abdominal Center
Date: 2020
Language: eng
Number of pages: 8
Belongs to series: Infection ecology & epidemiology
ISSN: 2000-8686
DOI: https://doi.org/10.1080/20008686.2020.1821513
URI: http://hdl.handle.net/10138/327504
Abstract: The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with 2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Subject: antibody test
COVID-19
disease severity and duration
IgM and IgG
SARS-CoV-2
serology assessment
immunoglobulin G antibody
immunoglobulin M antibody
aged
antibody response
Article
clinical article
cohort analysis
controlled study
coronavirus disease 2019
disease course
disease duration
female
hospitalization
human
immunoassay
male
nonhuman
population research
prospective study
real time polymerase chain reaction
sensitivity and specificity
Severe acute respiratory syndrome coronavirus 2
validation study
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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