Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test
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De Marinis , Y , Sunnerhagen , T , Bompada , P , Bläckberg , A , Yang , R , Svensson , J , Ekström , O , Eriksson , K-F , Hansson , O , Groop , L , Gonçalves , I & Rasmussen , M 2020 , ' Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test ' , Infection ecology & epidemiology , vol. 10 , no. 1 , 1821513 . https://doi.org/10.1080/20008686.2020.1821513
| Title: | Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| Author: | De Marinis, Yang; Sunnerhagen, Torgny; Bompada, Pradeep; Bläckberg, Anna; Yang, Runtao; Svensson, Joel; Ekström, Ola; Eriksson, Karl-Fredrik; Hansson, Ola; Groop, Leif; Gonçalves, Isabel; Rasmussen, Magnus |
| Contributor organization: | Institute for Molecular Medicine Finland Centre of Excellence in Complex Disease Genetics HUS Abdominal Center |
| Date: | 2020 |
| Language: | eng |
| Number of pages: | 8 |
| Belongs to series: | Infection ecology & epidemiology |
| ISSN: | 2000-8686 |
| DOI: | https://doi.org/10.1080/20008686.2020.1821513 |
| URI: | http://hdl.handle.net/10138/327504 |
| Abstract: | The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with 2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
| Subject: |
antibody test
COVID-19 disease severity and duration IgM and IgG SARS-CoV-2 serology assessment immunoglobulin G antibody immunoglobulin M antibody aged antibody response Article clinical article cohort analysis controlled study coronavirus disease 2019 disease course disease duration female hospitalization human immunoassay male nonhuman population research prospective study real time polymerase chain reaction sensitivity and specificity Severe acute respiratory syndrome coronavirus 2 validation study 3111 Biomedicine |
| Peer reviewed: | Yes |
| Rights: | cc_by |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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